Sung Ji-Hee, Kim Tae Hyun, Park Hyang Gi, Kim Min Ji, Kim Byoung-Gie, Kim Tae-Joong, Bae Duk-Soo
Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Obstet Gynecol Sci. 2013 Jan;56(1):41-4. doi: 10.5468/OGS.2013.56.1.41. Epub 2013 Jan 9.
Primary hepatoid carcinoma of the ovary (HCO) is a rare type of ovarian tumor that resembles hepatocellular carcinoma both histologically and immunohistochemically in its staining for alpha-fetoprotein (AFP). We describe a 51-year-old woman who presented to our hospital complaining of abdominal pain. Computed tomography scan revealed a large tumor in the pelvis. She underwent total hysterectomy and bilateral salpingo-oophorectomy with tumorectomy. A right ovarian mass measuring 9×8×6 cm was found. Histological diagnosis was hepatoid carcinoma of the right ovary. But, immunohistochemically, tumor cells were not immunoreactive for AFP and there was no elevation of serum AFP level. This is the first report of an ovarian carcinoma with typical histologic features of HCO with negative staining for AFP and normal level of serum AFP in the world.
原发性卵巢肝样癌（HCO）是一种罕见的卵巢肿瘤，在组织学和免疫组织化学上，其甲胎蛋白（AFP）染色类似于肝细胞癌。我们描述了一名51岁女性，她因腹痛前来我院就诊。计算机断层扫描显示盆腔有一个大肿瘤。她接受了全子宫切除术、双侧输卵管卵巢切除术及肿瘤切除术。发现右侧卵巢有一个大小为9×8×6 cm的肿块。组织学诊断为右侧卵巢肝样癌。但是，免疫组织化学检查显示肿瘤细胞对AFP无免疫反应，血清AFP水平也未升高。这是世界上首例具有典型HCO组织学特征、AFP染色阴性且血清AFP水平正常的卵巢癌报告。
