Takano Masashi, Shibasaki Tomoko, Sato Kimiya, Aida Shinsuke, Kikuchi Yoshihiro
Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, 359-8513, Japan.
Gynecol Oncol. 2003 Nov;91(2):444-8. doi: 10.1016/s0090-8258(03)00512-2.
Hepatoid adenocarcinoma is a rare tumor and has the histological coexistence of well-differentiated adenocarcinoma and nests of hepatoid cells with immunoreactivity for alpha-fetoprotein (AFP). A case of hepatoid adenocarcinoma in malignant mixed Mullerian tumor of the uterus is presented with a review of the literature.
The patient is a 63-year-old woman who complained of abnormal genital bleeding. Serum AFP concentration was 5060 ng/ml. Histologically, the tumor was composed of endometrioid adenocarcinoma, neoplastic hepatoid cells, and sarcoma component including leiomyosarcoma and rhabdomyosarcoma. After operation followed by six courses of platinum-based chemotherapy, serum levels of AFP dropped into normal range.
This is, to our knowledge, the first report of malignant mixed Mullerian tumor of the uterus with an AFP-producing hepatoid adenocarcinoma component.
肝样腺癌是一种罕见肿瘤，具有高分化腺癌与对甲胎蛋白（AFP）呈免疫反应的肝样细胞巢的组织学共存。本文报告1例子宫恶性混合性苗勒管肿瘤伴肝样腺癌，并复习相关文献。
患者为63岁女性，主诉生殖器异常出血。血清AFP浓度为5060 ng/ml。组织学检查显示，肿瘤由子宫内膜样腺癌、肿瘤性肝样细胞以及包括平滑肌肉瘤和横纹肌肉瘤在内的肉瘤成分组成。手术后进行6个疗程的铂类化疗后，血清AFP水平降至正常范围。
据我们所知，本文是子宫恶性混合性苗勒管肿瘤伴产生AFP的肝样腺癌成分的首例报告。
