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The miRNA-drug resistance connection: a new era of personalized medicine using noncoding RNA begins.

作者信息

Mishra Prasun J

出版信息

Pharmacogenomics. 2012 Sep;13(12):1321-4. doi: 10.2217/pgs.12.121.

DOI:10.2217/pgs.12.121
PMID:22966880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3464977/
Abstract
摘要

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MicroRNA polymorphisms: a giant leap towards personalized medicine.微小RNA多态性：迈向个性化医疗的巨大飞跃。
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Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.透明质酸-CD44与蛋白激酶C（ε）的相互作用通过干细胞标志物Nanog促进致癌信号传导并产生微小RNA-21，导致乳腺肿瘤细胞中肿瘤抑制蛋白PDCD4的下调、抗凋亡和化疗耐药。
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MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme.微小RNA-21靶向LRRFIP1并促进多形性胶质母细胞瘤对VM-26的耐药性。
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MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents.微小 RNA-200c 减轻侵袭性并恢复对微管靶向化疗药物的敏感性。
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