The miRNA-drug resistance connection: a new era of personalized medicine using noncoding RNA begins.
作者信息
Mishra Prasun J
出版信息
Pharmacogenomics. 2012 Sep;13(12):1321-4. doi: 10.2217/pgs.12.121.
Abstract
摘要
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Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.透明质酸-CD44与蛋白激酶C（ε）的相互作用通过干细胞标志物Nanog促进致癌信号传导并产生微小RNA-21，导致乳腺肿瘤细胞中肿瘤抑制蛋白PDCD4的下调、抗凋亡和化疗耐药。
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