Instituto de Investigación en Recursos Cinegéticos IREC, (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13071, Ciudad Real, Spain.
Vet Res. 2012 Sep 11;43(1):65. doi: 10.1186/1297-9716-43-65.
In late summer 2010 a mosquito born flavivirus not previously reported in Europe called Bagaza virus (BAGV) caused high mortality in red-legged partridges (Alectoris rufa) and ring-necked pheasants (Phasianus colchicus). We studied clinical findings, lesions and viral antigen distribution in naturally BAGV infected game birds in order to understand the apparently higher impact on red-legged partridges. The disease induced neurologic signs in the two galliform species and, to a lesser extent, in common wood pigeons (Columba palumbus). In red-legged partridges infection by BAGV caused severe haemosiderosis in the liver and spleen that was absent in pheasants and less evident in common wood pigeons. Also, BAGV antigen was present in vascular endothelium in multiple organs in red-legged partridges, and in the spleen in common wood pigeons, while in ring-necked pheasants it was only detected in neurons and glial cells in the brain. These findings indicate tropism of BAGV for endothelial cells and a severe haemolytic process in red-legged partridges in addition to the central nervous lesions that were found in all three species.
2010 年夏末，一种以前未在欧洲报道过的蚊媒黄病毒，即巴加病毒（BAGV），导致红腿鹧鸪（Alectoris rufa）和环颈雉（Phasianus colchicus）死亡率很高。我们研究了自然感染 BAGV 的猎鸟的临床发现、病变和病毒抗原分布，以了解其对红腿鹧鸪的明显更高影响。该疾病在两种雉科动物中引起神经症状，在普通斑鸠（Columba palumbus）中则较轻。在红腿鹧鸪中，BAGV 感染导致肝脏和脾脏严重的血色素沉着症，而在雉鸡中则没有，在普通斑鸠中则不太明显。此外，BAGV 抗原在红腿鹧鸪的多个器官的血管内皮中以及在普通斑鸠的脾脏中存在，而在环颈雉中仅在大脑的神经元和神经胶质细胞中检测到。这些发现表明 BAGV 对内皮细胞具有嗜性，并且除了在所有三种物种中发现的中枢神经系统病变外，在红腿鹧鸪中还存在严重的溶血性过程。
