Cork S C, Alley M R, Stockdale P H
Department of Veterinary Pathology and Public Health, Faculty of Veterinary Science, Massey University, Palmerston North, New Zealand.
Avian Pathol. 1995 Jun;24(2):239-54. doi: 10.1080/03079459508419066.
An experimental model of haemosiderosis, using the chicken, was developed to examine the distribution of iron in the liver following an injection of iron dextran and to allow calibration of image analysis readings. Image analysis was used as a tool to quantify the stainable iron present in hepatic tissue obtained from wild and captive birds presented for necropsy. A retrospective study of 180 necropsy cases, representing 40 different species of bird, is described. Statistical evaluation of the amount and distribution of stainable iron in the liver tissue of birds from different taxonomic orders indicated that the concentration of iron measured in liver tissue was significantly different in different species of bird. The results of the study showed that hepatic haemosiderosis is a common histological finding in most avian species examined. Although not necessarily associated with overt liver disease, it is often associated with concurrent malignant and infectious diseases. The presence of excess stainable iron in the liver is probably a reflection of an altered iron metabolism associated with increased turnover of tissue iron. This alteration may occur following starvation or trauma.
建立了一种利用鸡的血色素沉着症实验模型，以研究注射葡聚糖铁后肝脏中铁的分布情况，并对图像分析读数进行校准。图像分析被用作一种工具，用于量化从用于尸检的野生和圈养鸟类获得的肝组织中可染色铁的含量。本文描述了一项对180例尸检病例的回顾性研究，这些病例代表了40种不同的鸟类。对来自不同分类目的鸟类肝脏组织中可染色铁的含量和分布进行的统计评估表明，在不同鸟类物种中，肝脏组织中测得的铁浓度存在显著差异。研究结果表明，肝血色素沉着症是在所检查的大多数鸟类物种中常见的组织学发现。虽然不一定与明显的肝脏疾病相关，但它通常与并发的恶性和传染病有关。肝脏中存在过量的可染色铁可能反映了与组织铁周转率增加相关的铁代谢改变。这种改变可能发生在饥饿或创伤之后。
