2021年在葡萄牙检测到的巴加扎病毒的基因组特征及时空传播分析

Genome Characterization and Spaciotemporal Dispersal Analysis of Bagaza Virus Detected in Portugal, 2021.

作者信息

Falcão Marta, Barros Margarida, Duarte Margarida D, Santos Fábio Abade Dos, Fagulha Teresa, Henriques Margarida, Ramos Fernanda, Duarte Ana, Luís Tiago, Parreira Ricardo, Barros Sílvia C

机构信息

Institute of Hygiene and Tropical Medicine (IHMT), NOVA University of Lisbon, Rua da Junqueira 100, 1349-008 Lisbon, Portugal.

Faculdade de Ciências Médicas, NMS|FCM, NOVA Medical School, Universidade Nova de Lisboa, Campo dos Mártires da Pátria 130, 1169-056 Lisbon, Portugal.

出版信息

Pathogens. 2023 Jan 17;12(2):150. doi: 10.3390/pathogens12020150.

DOI:10.3390/pathogens12020150

PMID:36839422

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9962176/

Abstract

In September 2021, Bagaza virus (BAGV), a member of the Ntaya group from the genus, was detected for the first time in Portugal, in the heart and the brain of a red-legged partridge found dead in a hunting ground in Serpa (Alentejo region; southern Portugal). Here we report the genomic characterization of the full-length sequence of the BAGV detected (BAGV/PT/2021), including phylogenetic reconstructions and spaciotemporal analyses. Phylogenies inferred from nucleotide sequence alignments, complemented with the analysis of amino acid alignments, indicated that the BAGV strain from Portugal is closely related to BAGV strains previously detected in Spain, suggesting a common ancestor that seems to have arrived in the Iberia Peninsula in the late 1990s to early 2000s. In addition, our findings support previous observations that BAGV and Israel turkey meningoencephalitis virus (ITV) belong to the same viral species.

摘要

2021年9月，在葡萄牙塞尔帕（阿连特茹地区；葡萄牙南部）一处狩猎场发现一只死亡的红腿鹧鸪，在其心脏和大脑中首次检测到属于该属恩塔亚组的巴加扎病毒（BAGV）。在此，我们报告所检测到的巴加扎病毒（BAGV/PT/2021）全长序列的基因组特征，包括系统发育重建和时空分析。从核苷酸序列比对推断的系统发育，辅以氨基酸比对分析，表明来自葡萄牙的BAGV毒株与先前在西班牙检测到的BAGV毒株密切相关，这表明一个共同祖先似乎在20世纪90年代末至21世纪初抵达伊比利亚半岛。此外，我们的研究结果支持了之前的观察结果，即BAGV和以色列火鸡脑膜脑炎病毒（ITV）属于同一病毒物种。