Ianconescu M, Hornstein K, Samberg Y, Aharonovici A, Merdinger M
Kimron Veterinary Institute, Tel-Aviv University, Beit-Dagan, Israel.
Avian Pathol. 1975;4(2):119-31. doi: 10.1080/03079457509353858.
Turkey meningo-encephalitis virus could be adapted to the Japanese quail by intra-cerebral inoculation. After 4 passages the virus was found to be less pathogenic for the turkey. Further attenuation could be achieved by growing the virus in Japanese quail kidney cell cultures for 11 passages. This attenuated virus was used for the preparation of a live vaccine against turkey meningo-encephalitis. The safety and efficacy of the vaccine was shown in laboratory and field experiments.
火鸡脑膜脑炎病毒可通过脑内接种适应日本鹌鹑。经过4代传代后，发现该病毒对火鸡的致病性降低。通过在日本鹌鹑肾细胞培养物中传代培养该病毒11代可进一步减毒。这种减毒病毒用于制备抗火鸡脑膜脑炎的活疫苗。该疫苗的安全性和有效性在实验室和田间试验中得到了证明。
