基于醚-咪唑𬭩卡宾的杂芳基氯代物与芳基/杂芳基硼酸试剂的铃木-宫浦偶联反应。
Ether-imidazolium carbenes for Suzuki-Miyaura cross-coupling of heteroaryl chlorides with aryl/heteroarylboron reagents.
机构信息
Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
出版信息
Org Lett. 2013 Jun 7;15(11):2716-9. doi: 10.1021/ol4010189. Epub 2013 May 28.
PMID:23713985
Abstract
Easily accessible and handled ether-imidazolium chlorides were developed as ligand precursors. The coupling reactions of heteroaryl chlorides with aryl/heteroarylboronic acids and esters were catalyzed by the palladium/ether-imidazolium chloride system with high substrate tolerance to give various heterobiaryls in good to excellent yields.
摘要
易于获取和处理的醚-咪唑啉氯化物被开发为配体前体。杂芳基氯化物与芳基/杂芳基硼酸和酯的偶联反应由钯/醚-咪唑啉氯化物体系催化，对底物具有高耐受性，以良好至优异的收率得到各种杂联芳烃。
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