Department of Dermatology, Broadgreen Hospital, Liverpool, United Kingdom.
J Low Genit Tract Dis. 2012 Oct;16(4):468-70. doi: 10.1097/LGT.0b013e31825e9b18.
We report 3 patients with long-standing lichen sclerosus who subsequently developed new onset erosive disease in affected sites. Repeated biopsies were performed which, although not diagnostic, showed some features of bullous pemphigoid for 1 patient and nonspecific findings for the 2 others. Direct immunofluorescence showed the characteristic findings of bullous pemphigoid in the first and pemphigus vulgaris in the others. All 3 patients were treated with immunosuppressive agents, and their condition improved dramatically.
我们报告了 3 例患有长期硬化性苔藓的患者，随后在受累部位出现了新的侵蚀性疾病。进行了多次活检，虽然没有明确诊断，但其中 1 例显示出大疱性类天疱疮的一些特征，另外 2 例则显示出非特异性发现。直接免疫荧光检查显示，第 1 例患者具有大疱性类天疱疮的特征性表现，另外 2 例患者则具有寻常型天疱疮的特征性表现。所有 3 例患者均接受了免疫抑制剂治疗，病情显著改善。
