Department of Urology, Hanyang University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2012 Sep;27(9):973-80. doi: 10.3346/jkms.2012.27.9.973. Epub 2012 Aug 22.
Low quality clinical trials have a possibility to have errors in the process of deriving the results and therefore distort the study. Quality assessment of clinical trial is necessary in order to prevent any clinical application erroneous results is important. Randomized controlled trial (RCT) is a design for evaluate the effectiveness of medical procedure. This study was conducted by extracting the RCTs from the original articles published in the Journal of Korean Medical Science (JKMS) from 1986 to 2011 and conducting a qualitative analysis using three types of analysis tools: Jadad scale, van Tulder scale and Cochrane Collaboration risk of bias Tool. To compare the quality of articles of JKMS, quality analysis of the RCTs published in Yonsei Medical Journal (YMJ) and Korean Journal of Internal Medicine was also conducted. In the JKMS, YMJ and Korean Journal of Internal Medicine, the quantitative increase of RCT presented over time was observed but no qualitative improvement of RCT was observed over time. From the results of this study, it is required for the researchers to plan for and perform higher quality studies.
低质量临床试验有可能在结果推导过程中出现错误，从而扭曲研究结果。为了防止任何临床应用出现错误的结果，有必要对临床试验进行质量评估。随机对照试验（RCT）是评估医疗程序有效性的设计。本研究从《韩国医学科学杂志》（JKMS）1986 年至 2011 年发表的原始文章中提取 RCT，并使用三种分析工具进行定性分析：Jadad 量表、van Tulder 量表和 Cochrane 协作风险偏倚工具。为了比较 JKMS 文章的质量，还对《延世医学杂志》（YMJ）和《韩国内科医学杂志》发表的 RCT 进行了质量分析。在 JKMS、YMJ 和《韩国内科医学杂志》中，随着时间的推移，RCT 的数量呈定量增加，但 RCT 的质量没有随时间的推移而改善。从这项研究的结果来看，研究人员需要计划并进行更高质量的研究。
