Evans Anthony, Costello Eithne
Liverpool Cancer Research UK Centre, University of Liverpool Liverpool, UK.
Front Physiol. 2012 Jul 13;3:270. doi: 10.3389/fphys.2012.00270. eCollection 2012.
The pancreatic ductal adenocarcinoma (PDAC) microenvironment accommodates a variety of cell types and a plethora of complex interactions between tumor cells, host cells and extracellular matrix (ECM) components. Here we review the role of inflammatory cells, in particular mast cells, myeloid-derived suppressor cells, macrophages, T regulatory cells, T helper cells and neutrophils. The picture that emerges is that of a tumor microenvironment, in which the immune response is actively suppressed, and inflammatory cells contribute in a variety of ways to tumor progression.
胰腺导管腺癌（PDAC）的微环境包含多种细胞类型，以及肿瘤细胞、宿主细胞和细胞外基质（ECM）成分之间大量复杂的相互作用。在此，我们综述炎症细胞的作用，特别是肥大细胞、髓源性抑制细胞、巨噬细胞、调节性T细胞、辅助性T细胞和中性粒细胞。呈现出的情况是肿瘤微环境中免疫反应被积极抑制，炎症细胞以多种方式促进肿瘤进展。
