Endocrine Key Laboratory of the Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China.
Int J Endocrinol. 2012;2012:359724. doi: 10.1155/2012/359724. Epub 2012 Aug 30.
Serum resistin was initially hypothesized as a link between obesity and insulin resistance in mice. The latest evidence suggests that serum resistin is proinflammatory cytokines. Inflammation plays a key role in the pathogenesis of type 2 diabetes mellitus (T2DM). Many reports have previously identified changed serum resistin levels in patients with T2DM, but little is known of the levels of resistin in saliva. In our study, saliva and serum samples were collected from 38 patients with newly diagnosed T2DM at each time point of OGTT and 35 nondiabetic controls at fasting state. Resistin concentrations were measured using ELISA. We have demonstrated the presence of resistin in saliva of T2DM and nondiabetic subjects. Saliva resistin levels of T2DM are significantly higher than those of nondiabetic controls. Resistin levels in saliva are not affected by eating activity and correlated with serum resistin levels at any time points of OGTT. A positive correlation of serum and salivary resistin with BMI and HOMA-IR existed in T2DM. Measurement of resistin in saliva is a simple, noninvasive and may be an acceptable alternative to blood sampling for evaluatinginflammation/obesity/insulin resistance state.
血清抵抗素最初被假设为肥胖与胰岛素抵抗在老鼠之间的联系。最新证据表明，血清抵抗素是促炎细胞因子。炎症在 2 型糖尿病（T2DM）发病机制中起关键作用。许多报道先前已经确定了 T2DM 患者的血清抵抗素水平发生了变化，但对于唾液中的抵抗素水平知之甚少。在我们的研究中，在 OGTT 的每个时间点以及 35 名非糖尿病对照者的空腹状态下，从 38 名新诊断为 T2DM 的患者中收集了唾液和血清样本。使用 ELISA 测量抵抗素浓度。我们已经证明了 T2DM 和非糖尿病受试者的唾液中存在抵抗素。T2DM 的唾液抵抗素水平明显高于非糖尿病对照组。唾液中的抵抗素水平不受进食活动的影响，并且与 OGTT 的任何时间点的血清抵抗素水平相关。T2DM 中血清和唾液抵抗素与 BMI 和 HOMA-IR 呈正相关。在评估炎症/肥胖/胰岛素抵抗状态时，唾液中的抵抗素测量是一种简单、无创的替代采血的方法。
