Abdalla Mona Mohamed Ibrahim
Human Biology Department, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia.
World J Diabetes. 2021 Sep 15;12(9):1507-1517. doi: 10.4239/wjd.v12.i9.1507.
The escalating global burden of type 2 diabetes mellitus necessitates the implementation of strategies that are both more reliable and faster in order to improve the early identification of insulin resistance (IR) in high-risk groups, including overweight and obese individuals. The use of salivary biomarkers offers a promising alternative to serum collection because it is safer, more comfortable, and less painful to obtain saliva samples. As obesity is the foremost contributory factor in IR development, the adipocytokines such as leptin, adiponectin, resistin, and visfatin secreted from the adipose tissue have been studied as potential reliable biomarkers for IR. Measurement of salivary adipokines as predictors for IR has attracted widespread attention because of the strong correlation between their blood and salivary concentrations. One of the adipokines that is closely related to IR is resistin. However, there are conflicting findings on resistin's potential role as an etiological link between obesity and IR and the reliability of measuring salivary resistin as a biomarker for IR. Hence this study reviewed the available evidence on the potential use of salivary resistin as a biomarker for IR in order to attempt to gain a better understanding of the role of resistin in the development of IR in obese individuals.
2型糖尿病日益加重的全球负担使得有必要实施更可靠、更快速的策略，以改善对高危人群（包括超重和肥胖个体）胰岛素抵抗（IR）的早期识别。使用唾液生物标志物为血清采集提供了一种有前景的替代方法，因为获取唾液样本更安全、更舒适且痛苦更小。由于肥胖是IR发生的首要促成因素，脂肪组织分泌的瘦素、脂联素、抵抗素和内脂素等脂肪细胞因子已被作为IR潜在的可靠生物标志物进行研究。由于唾液脂肪细胞因子与血液中浓度之间存在强相关性，因此将唾液脂肪细胞因子作为IR的预测指标已引起广泛关注。与IR密切相关的脂肪细胞因子之一是抵抗素。然而，关于抵抗素作为肥胖与IR之间病因联系的潜在作用以及将唾液抵抗素作为IR生物标志物测量的可靠性，存在相互矛盾的研究结果。因此，本研究回顾了关于唾液抵抗素作为IR生物标志物潜在用途的现有证据，以便更好地了解抵抗素在肥胖个体IR发生中的作用。
