Nakayama Yoshifumi, Torigoe Takayuki, Inoue Yuzuru, Minagawa Noritaka, Izumi Hiroto, Kohno Kimitoshi, Yamaguchi Koji
Departments of Surgery 1, and.
Exp Ther Med. 2012 Jan;3(1):25-30. doi: 10.3892/etm.2011.361. Epub 2011 Oct 7.
Cancer cells generally have a high rate of glycolysis and produce larger quantities of lactate as compared to the surrounding normal cells. Monocarboxylate transporter 4 (MCT4) is one of the proton pumps exchanging the lactate through the plasma membrane. The prognostic significance of MCT4 expression has not been evaluated in patients with colorectal cancer (CRC). Surgical specimens from 105 CRC patients were immunohistochemically stained using a polyclonal anti-MCT4 antibody. The relationships among the MCT4 expression, clinicopathological factors and prognosis were evaluated. A total of 53 (50.5%) of the 105 patients with CRC were determined to have tumors positive for MCT4 expression. The expression of MCT4 significantly correlated with the tumor size, depth of invasion, lymph node metastasis, distant metastasis and TNM staging. The survival rate of the patients who were positive for MCT4 expression was significantly lower than that of patients with negative MCT4 expression. Positive MCT4 expression was a significantly poor prognostic factor, as determined by both univariate and multivariate analyses. Therefore, positive MCT4 expression appears to be a useful marker for tumor progression and prognosis in patients with CRC.
与周围正常细胞相比，癌细胞通常具有较高的糖酵解速率，并产生大量乳酸。单羧酸转运蛋白4（MCT4）是通过质膜交换乳酸的质子泵之一。MCT4表达的预后意义尚未在结直肠癌（CRC）患者中进行评估。使用多克隆抗MCT4抗体对105例CRC患者的手术标本进行免疫组织化学染色。评估了MCT4表达、临床病理因素与预后之间的关系。105例CRC患者中共有53例（50.5%）被确定为MCT4表达阳性的肿瘤。MCT4的表达与肿瘤大小、浸润深度、淋巴结转移、远处转移和TNM分期显著相关。MCT4表达阳性患者的生存率显著低于MCT4表达阴性的患者。单因素和多因素分析均表明，MCT4表达阳性是一个显著不良的预后因素。因此，MCT4表达阳性似乎是CRC患者肿瘤进展和预后的一个有用标志物。
