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SET8基因3'非翻译区中miR - 502结合位点的多态性与小细胞肺癌的预后相关。

A polymorphism at the miR-502 binding site in the 3' untranslated region of the SET8 gene is associated with the outcome of small-cell lung cancer.

作者信息

Ding Cuimin, Li Ruijuan, Peng Jingcui, Li Shengmian, Guo Zhanjun

机构信息

Departments of Respiratory Medicine, and.

出版信息

Exp Ther Med. 2012 Apr;3(4):689-692. doi: 10.3892/etm.2012.469. Epub 2012 Feb 3.

DOI:10.3892/etm.2012.469
PMID:22969952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438626/
Abstract

microRNAs (miRNAs) bind to the 3' untranslated regions (UTRs) of messenger RNAs, where they interfere with translation of genes that regulate cell differentiation, apoptosis and tumourigenesis. The histone methyltransferase SET8 has been reported to methylate TP53 and regulate genomic stability. We analysed a single nucleotide polymorphism (rs16917496) within the miR-502 miRNA seed region at the 3' UTR of SET8 in small-cell lung cancer (SCLC) patients. The SET8 CC+CT genotype was identified to be independently associated with longer survival in SCLC patients by multivariate analysis (relative risk, 0.453; 95% CI 0.217-0.944; p=0.035). The analysis of genetic polymorphisms in miRNA binding sites may help to identify patient subgroups at high risk of poor outcome.

摘要

微小RNA（miRNA）与信使核糖核酸（mRNA）的3'非翻译区（UTR）结合，在那里它们干扰调节细胞分化、凋亡和肿瘤发生的基因的翻译。据报道，组蛋白甲基转移酶SET8可使TP53甲基化并调节基因组稳定性。我们分析了小细胞肺癌（SCLC）患者中SET8的3'UTR处miR-502 miRNA种子区域内的单核苷酸多态性（rs16917496）。通过多变量分析确定，SET8 CC+CT基因型与SCLC患者的较长生存期独立相关（相对风险，0.453；95%可信区间0.217-0.944；p=0.035）。对miRNA结合位点的基因多态性分析可能有助于识别预后不良高风险的患者亚组。

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A polymorphism at the miR-502 binding site in the 3'-untranslated region of the histone methyltransferase SET8 is associated with hepatocellular carcinoma outcome.miR-502 结合位点的多态性位于组蛋白甲基转移酶 SET8 的 3'-非翻译区，与肝细胞癌的预后相关。
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