MTA2过表达与食管鳞状细胞癌肿瘤进展之间的相关性
Correlation between MTA2 overexpression and tumour progression in esophageal squamous cell carcinoma.
作者信息
Liu Y P, Shan B E, Wang X L, Ma L
机构信息
Department of Pathology;
出版信息
Exp Ther Med. 2012 Apr;3(4):745-749. doi: 10.3892/etm.2012.475. Epub 2012 Feb 7.
Abstract
The aim of this study was to clarify the clinicopathological outcome and prognostic significance of metastasis-associated gene 2 (MTA2) in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining for MTA2 was performed on surgical specimens obtained from 162 patients with ESCC. Relationships between MTA2 expression and clinicopathological factors, including prognosis, were analyzed. Significant correlations were noted among MTA2 overexpression and TNM clinical classification staging, depth of invasion, presence of regional lymph node metastasis, presence of distant metastasis, lymphatic invasion, blood-vessel invasion and the 5-year survival rates. The expression of MTA2 protein was correlated with tumour progression. Patients with MTA2 overexpression tended to have poor prognosis compared to patients with MTA2 underexpression.
摘要
本研究旨在阐明转移相关基因2（MTA2）在食管鳞状细胞癌（ESCC）中的临床病理结果及预后意义。对162例ESCC患者手术标本进行MTA2免疫组织化学染色。分析MTA2表达与包括预后在内的临床病理因素之间的关系。MTA2过表达与TNM临床分类分期、浸润深度、区域淋巴结转移情况、远处转移情况、淋巴管浸润、血管浸润及5年生存率之间存在显著相关性。MTA2蛋白表达与肿瘤进展相关。与MTA2低表达患者相比，MTA2过表达患者预后往往较差。
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