Duodecim. 2012;128(15):1620-1.
Psoriasis is a chronic, immune-mediated, inflammatory disorder of the skin and joints. Moderate-to-severe cases are associated with an independent risk of comorbidity (cardiovascular diseases and diabetes) even after adjusting for risk factors, known to be more prevalent in psoriatics compared to normal population. The underlying systemic inflammation, analogous to that observed in rheumatoid arthritis, calls for a long-term effective treatment. Screening and treatment of cardiovascular risk factors is highly recommended. The biologic drug arsenal has new additions. Long term treatment data from clinical study extensions and independent registries are reviewed.
银屑病是一种慢性、免疫介导的皮肤和关节炎症性疾病。即使在调整了已知在银屑病患者中比正常人群更普遍的危险因素后，中重度病例仍存在合并症（心血管疾病和糖尿病）的独立风险。与类风湿性关节炎中观察到的情况类似，潜在的全身炎症需要长期有效的治疗。强烈建议对心血管危险因素进行筛查和治疗。生物药物库有了新的补充。对来自临床研究扩展和独立登记处的长期治疗数据进行了综述。
