Guangdong Open Access Laboratory of Agricultural Product Processing, Sericulture and Farm Produce Processing Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, PR China.
Nat Prod Res. 2013;27(14):1237-41. doi: 10.1080/14786419.2012.724414. Epub 2012 Sep 13.
One new flavanocoumarin, flemicoumarin A (1) was isolated from the EtOAc-soluble partition of the root of Flemingia philippinensis, along with three known compounds, namely 4,2'-epoxy-4',5-dihydroxy-7,5'-dimethoxy-3-phenylcoumarin (2), kaempferol 6-C-glucoside (3) and dracocephaloside (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR, CD and MS data. The structures of the known compounds were identified by comparison of their spectroscopic data with those reported in the literature. Compounds 1-4 exhibited inactivity against MCF-7, A549 and Hep-G2 human cancer cell lines in vitro by MTT colorimetric assay.
从 Flemingia philippinensis 的根的 EtOAc 可溶部分分离得到一种新的黄烷酮，即 Flemingicoumarin A（1），此外还分离得到三种已知化合物，分别为 4,2'-环氧-4',5-二羟基-7,5'-二甲氧基-3-苯基香豆素（2）、山奈酚 6-C-葡萄糖苷（3）和 dracocephaloside（4）。根据其 1D、2D NMR、CD 和 MS 数据，确定了化合物 1 的结构。通过与文献报道的光谱数据进行比较，鉴定了已知化合物的结构。通过 MTT 比色法测定，化合物 1-4 对 MCF-7、A549 和 Hep-G2 人癌细胞系在体外均无活性。
