从 Flemingia philippinensis 中提取到具有免疫抑制活性的新香豆素。
A new coumestan with immunosuppressive activities from Flemingia philippinensis.
机构信息
Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Fitoterapia. 2011 Jun;82(4):615-9. doi: 10.1016/j.fitote.2011.01.019. Epub 2011 Jan 28.
A new coumestan, 1,3,9-trihydroxy-8-methoxycoumestan, named flemicoumestan A 1 together with nine isoflavone-related compounds were isolated from the ethyl acetate extract of the roots of Flemingia philippinensis. Their structures were elucidated and confirmed by spectroscopic methods and literature data. Compounds 3 and 4 showed strong lymphocyte proliferation inhibitory activity with an IC(50) value of 1.04-2.76 μM, and the low cytotoxicity with the CC(50) value of 71.01 and 56.36 μM, respectively.
一种新的香豆素化合物，1,3,9-三羟基-8-甲氧基香豆素，被命名为 Flemingia philippinensis 根的乙酸乙酯提取物中的 Flemingicoumestan A1，以及其他 9 种异黄酮相关化合物。通过光谱方法和文献数据确定了它们的结构。化合物 3 和 4 显示出强烈的淋巴细胞增殖抑制活性，IC50 值为 1.04-2.76 μM，且细胞毒性较低，CC50 值分别为 71.01 和 56.36 μM。
Zotero 插件