Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
J Cutan Med Surg. 2012 Sep-Oct;16(5):375-7. doi: 10.1177/120347541201600520.
Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma, with a predilection for the head and neck region. There are only two case reports in the literature documenting a nasal cavity squamous cell carcinoma presenting as a primary cutaneous lesion.
We report a rare case of nasal cavity basaloid squamous cell carcinoma presenting initially as a nasal bridge mass. Two initial biopsies revealed features consistent with basal cell carcinoma and basosquamous cell carcinoma, respectively.
Final surgical pathology showed extensive invasive squamous cell carcinoma with basaloid differentiation arising from the nasal septal mucosa with extension to the overlying skin. The clinicopathologic features were interpreted as basaloid squamous cell carcinoma.
We discuss the difficulties in pathologic diagnosis of this condition given its varied phenotypical expression. As well, this case emphasizes the necessity for diagnostic vigilance when assessing a primary cutaneous lesion as it may be a rare presentation of an underlying malignancy extending to the skin.
基底样鳞状细胞癌是一种罕见的侵袭性鳞状细胞癌，好发于头颈部。文献中仅有两例报告记录鼻腔鳞状细胞癌表现为原发性皮肤病变。
我们报告一例罕见的鼻腔基底样鳞状细胞癌，最初表现为鼻桥肿块。两次初始活检分别显示符合基底细胞癌和基底鳞状细胞癌的特征。
最终的外科病理显示，源自鼻中隔黏膜的广泛侵袭性鳞状细胞癌伴基底样分化，并向覆盖的皮肤延伸。临床病理特征被解读为基底样鳞状细胞癌。
鉴于其多种表型表达，我们讨论了这种情况下病理诊断的困难。此外，该病例强调了在评估原发性皮肤病变时保持诊断警惕的必要性，因为它可能是潜在恶性肿瘤向皮肤延伸的罕见表现。
