Vesoulis Z
Department of Pathology, Akron City Hospital (Summa Health Systems), Ohio 44309, USA.
Acta Cytol. 1998 May-Jun;42(3):783-7. doi: 10.1159/000331847.
First described in 1986, the basaloid squamous variant of laryngeal carcinoma is an uncommon, aggressive neoplasm with early presentation of metastatic disease and widespread dissemination. It is characterized primarily by its biphasic morphologic appearance.
A 64-year-old female smoker presented with left hilar and right lower lung lobe masses. The fine needle aspiration cytologic findings were consistent with features of primary undifferentiated small cell carcinoma.
The basaloid squamous cell carcinoma of head and neck region is a highly malignant neoplasm with frequent metastatic disease at the time of diagnosis. Metastatic deposits may consist of basaloid and/or squamous carcinoma cells. The basaloid component of this biphasic neoplasm is poorly differentiated and demonstrates cytologic features that mimic undifferentiated small cell carcinoma. Previous reports of cervical lymph node metastases from basaloid squamous carcinoma indicate frequent misdiagnosis as small cell carcinoma. Pulmonary metastases are more problematic since they introduce the possibility of a second primary lesion in these patients who have a frequent history of cigarette and/or ethanol abuse. Immunohistochemistry is useful in the distinction of metastatic basaloid squamous carcinoma from a second primary cell carcinoma of the lung.
喉癌的基底样鳞状细胞变异型于1986年首次被描述，是一种罕见的侵袭性肿瘤，早期即出现转移性疾病且广泛播散。其主要特征为双相形态学表现。
一名64岁吸烟女性，出现左肺门和右下肺叶肿块。细针穿刺细胞学检查结果与原发性未分化小细胞癌特征相符。
头颈部基底样鳞状细胞癌是一种高度恶性肿瘤，诊断时常有转移性疾病。转移灶可能由基底样和/或鳞状癌细胞组成。这种双相肿瘤的基底样成分分化差，表现出类似未分化小细胞癌的细胞学特征。既往关于基底样鳞状癌颈部淋巴结转移的报道表明，常被误诊为小细胞癌。肺转移更具问题，因为在这些有频繁吸烟和/或乙醇滥用史的患者中，可能存在第二个原发性病变。免疫组织化学有助于区分转移性基底样鳞状癌与肺的第二个原发性细胞癌。
