Tumormicroenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Tumormicroenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
J Invest Dermatol. 2012 Oct;132(10):2317-2319. doi: 10.1038/jid.2012.220.
It has been shown that a side population (SP), which is characterized by high chemical efflux capacity, is present in human melanoma cell lines. However, it was not clear whether patients' samples contain the same subpopulation. In this issue, Luo et al. (2012) report that they have isolated SP cells directly from patients' melanomas. SP cells are resistant to paclitaxel because of the upregulation of ABCB1 and ABCB5. Notably, these cells are also resistant to temozolomide, which is not a substrate for ATP-Binding Cassette (ABC) transporters, in an interleukin (IL)-8-dependent manner. This study provides novel clues for understanding how a small, but critical, subpopulation within melanomas is resistant to therapies.
已有研究表明,人黑色素瘤细胞系中存在一个具有高化学外排能力的侧群(SP)。然而,尚不清楚患者样本中是否存在相同的亚群。在本期杂志中,Luo 等人(2012)报道称,他们已直接从患者的黑色素瘤中分离出 SP 细胞。由于 ABCB1 和 ABCB5 的上调,SP 细胞对紫杉醇具有耐药性。值得注意的是,这些细胞对 IL-8 依赖性而非 ABC 转运体底物替莫唑胺也具有耐药性。该研究为理解黑色素瘤中一小部分但至关重要的亚群对治疗产生耐药性的机制提供了新的线索。