Department of Analytical Chemistry, Medical University of Bialystok, 15-089 Białystok, Poland.
Int J Mol Sci. 2022 Dec 21;24(1):115. doi: 10.3390/ijms24010115.
ABC transporters are expressed in skin cells to protect them against harmful xenobiotics. Moreover, these transmembrane proteins have a number of additional functions that ensure skin homeostasis. This review summarizes the current knowledge about the role of specific ABC proteins in the skin, including multi-drug resistance transporters (MDR1/3), the transporter associated with antigen processing 1/2 (TAP1/2), the cystic fibrosis transmembrane conductance regulator (CFTR), sulfonylurea receptors (SUR1/2), and the breast cancer resistance protein (BCRP). Additionally, the effect of UV radiation on ABC transporters is shown. The exposure of skin cells to UV radiation often leads to increased activity of ABC transporters-as has been observed in the case of MDRs, TAPs, CFTR, and BCRP. A different effect of oxidative stress has been observed in the case of mitochondrial SURs. However, the limited data in the literature-as indicated in this article-highlights the limited number of experimental studies dealing with the role of ABC transporters in the physiology and pathophysiology of skin cells and the skin as a whole. At the same time, the importance of such knowledge in relation to the possibility of daily exposure to UV radiation and xenobiotics, used for both skin care and the treatment of its diseases, is emphasized.
ABC 转运蛋白在皮肤细胞中表达，以保护它们免受有害的异生物质的侵害。此外，这些跨膜蛋白还有许多其他功能，可以确保皮肤的内稳态。这篇综述总结了特定 ABC 蛋白在皮肤中的作用的最新知识，包括多药耐药转运蛋白（MDR1/3）、抗原加工相关转运体 1/2（TAP1/2）、囊性纤维化跨膜电导调节因子（CFTR）、磺酰脲受体（SUR1/2）和乳腺癌耐药蛋白（BCRP）。此外，还展示了紫外线辐射对 ABC 转运蛋白的影响。皮肤细胞暴露于紫外线辐射通常会导致 ABC 转运蛋白的活性增加，正如在 MDR、TAP、CFTR 和 BCRP 的情况下所观察到的那样。线粒体 SUR 的氧化应激的影响则不同。然而，文献中的有限数据——正如本文所指出的——突出了处理 ABC 转运蛋白在皮肤细胞和皮肤整体生理学和病理生理学中的作用的实验研究数量有限。同时，鉴于日常生活中每天都会接触到紫外线辐射和异生物质，这些知识对于皮肤护理和皮肤疾病治疗的重要性也得到了强调。
