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Synthesis of sphingolipids with an ω-esterified long acyl chain, ceramide components of the human epidermis.

作者信息

Tashiro Takuya, Mori Kenji

机构信息

Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

出版信息

Biosci Biotechnol Biochem. 2012;76(9):1715-20. doi: 10.1271/bbb.120333. Epub 2012 Sep 7.

DOI:10.1271/bbb.120333
PMID:22972337
Abstract

Esterified ceramides, (2S,3R,4E)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3-diol (2) and (2S,3R,4E,6R)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3,6-triol (4), are minor components of the human stratum corneum. We synthesized these ceramides by employing olefin cross metathesis as the key reaction for constructing their ω-hydroxytriacontanoyl part (13).

摘要

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