Synthesis of sphingolipids with an ω-esterified long acyl chain, ceramide components of the human epidermis.
作者信息
Tashiro Takuya, Mori Kenji
机构信息
Glycosphingolipid Synthesis Group, Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
出版信息
Biosci Biotechnol Biochem. 2012;76(9):1715-20. doi: 10.1271/bbb.120333. Epub 2012 Sep 7.
PMID:22972337
Abstract
Esterified ceramides, (2S,3R,4E)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3-diol (2) and (2S,3R,4E,6R)-2-[(30'-stearoyloxy)triacontanamido]octadec-4-ene-1,3,6-triol (4), are minor components of the human stratum corneum. We synthesized these ceramides by employing olefin cross metathesis as the key reaction for constructing their ω-hydroxytriacontanoyl part (13).
摘要
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