Dunston G M, Halder R M
Department of Dermatology, Howard University School of Medicine, Washington, DC.
Arch Dermatol. 1990 Jan;126(1):56-60.
We have determined the HLA-DR and HLA-DQ phenotypes of 24 black patients with vitiligo and compared these with phenotypes of 143 local black controls. HLA-DR4 was significantly increased in patients, 38% vs 11% for controls. HLA-DQw3 was also increased in patients, 58% vs 32% for controls and may be explained in part by linkage disequilibrium with HLA-DR4. When patients were subgrouped according to family history of autoimmune disease and compared with controls, the increase in HLA-DR4 and HLA-DQw3 segregated with a positive family history. HLA-DRw6 in patients with a negative family history of autoimmune disease (64%) was significantly greater than the 10% in patients with a positive family history. When patients were subgrouped according to age at onset of disease, HLA-DR4 was increased in those with early onset of disease (younger than 20 years) while HLA-DRw6 was greater in patients who were older at onset of disease. These findings support the hypothesis of an immunogenetic influence on the expression of vitiligo in black patients with vitiligo.
我们已确定了24例白癜风黑人患者的HLA - DR和HLA - DQ表型，并将其与143名当地黑人对照的表型进行了比较。患者中HLA - DR4显著增加，对照组为11%，患者组为38%。患者中HLA - DQw3也增加，对照组为32%，患者组为58%，这可能部分是由于与HLA - DR4的连锁不平衡所致。当根据自身免疫性疾病家族史对患者进行亚组划分并与对照组比较时，HLA - DR4和HLA - DQw3的增加与阳性家族史相关。自身免疫性疾病家族史阴性的患者中HLA - DRw6（64%）显著高于家族史阳性患者中的10%。当根据疾病发病年龄对患者进行亚组划分时，疾病早发（20岁以下）的患者中HLA - DR4增加，而发病年龄较大的患者中HLA - DRw6更多。这些发现支持了免疫遗传学对白癜风黑人患者白癜风表达有影响这一假说。
