现代白癜风遗传学为这一古老疾病带来新曙光。
Modern vitiligo genetics sheds new light on an ancient disease.
机构信息
Human Medical Genetics and Genomics Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
出版信息
J Dermatol. 2013 May;40(5):310-8. doi: 10.1111/1346-8138.12147.
Abstract
Vitiligo is a complex disorder in which autoimmune destruction of melanocytes results in white patches of skin and overlying hair. Over the past several years, extensive genetic studies have outlined a biological framework of vitiligo pathobiology that underscores its relationship to other autoimmune diseases. This biological framework offers insight into both vitiligo pathogenesis and perhaps avenues towards more effective approaches to treatment and even disease prevention.
摘要
白癜风是一种复杂的疾病，其特征是自身免疫破坏黑色素细胞，导致皮肤和毛发出现白色斑块。在过去的几年中，大量的遗传研究概述了白癜风病理生物学的生物学框架，强调了它与其他自身免疫性疾病的关系。这个生物学框架为白癜风的发病机制提供了深入的了解，也许还为更有效的治疗方法甚至疾病预防提供了途径。
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本文引用的文献
1
Vitiligo in the Ssk Community of Bangalore (a Preliminary Report).
Indian J Dermatol Venereol Leprol. 1988 Sep-Oct;54(5):251-254.
2
NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome.
Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2952-6. doi: 10.1073/pnas.1222808110. Epub 2013 Feb 4.
3
Risk of generalized vitiligo is associated with the common 55R-94A-247H variant haplotype of GZMB (encoding granzyme B).
J Invest Dermatol. 2013 Jun;133(6):1677-9. doi: 10.1038/jid.2013.5. Epub 2013 Jan 15.
4
Association of generalized vitiligo with MHC class II loci in patients from the Indian subcontinent.
J Invest Dermatol. 2013 May;133(5):1369-72. doi: 10.1038/jid.2012.501. Epub 2013 Jan 10.
5
Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin.
PLoS One. 2012;7(12):e51040. doi: 10.1371/journal.pone.0051040. Epub 2012 Dec 10.
6
Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility.
Arch Dermatol Res. 2013 Apr;305(3):233-9. doi: 10.1007/s00403-012-1301-x. Epub 2012 Nov 21.
7
Association study between polymorphisms of CD28, CTLA4 and ICOS and non-segmental vitiligo in a Korean population.
Exp Ther Med. 2011 Nov;2(6):1145-1149. doi: 10.3892/etm.2011.326. Epub 2011 Aug 3.
8
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
J Invest Dermatol. 2013 Feb;133(2):403-10. doi: 10.1038/jid.2012.320. Epub 2012 Sep 6.
9
Serum homocysteine, vitamin B12, folic acid levels and methylenetetrahydrofolate reductase (MTHFR) gene polymorphism in vitiligo.
Dis Markers. 2012;33(2):85-9. doi: 10.3233/DMA-2012-0908.
10
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
Nat Genet. 2012 May 6;44(6):676-80. doi: 10.1038/ng.2272.
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