Centre for Genomic Regulation, Barcelona 08003, Spain.
Genes Dev. 2012 Oct 1;26(19):2144-53. doi: 10.1101/gad.192294.112. Epub 2012 Sep 12.
Altered stem cell homeostasis is linked to organismal aging. However, the mechanisms involved remain poorly understood. Here we report novel alterations in hair follicle stem cells during skin aging, including increased numbers, decreased function, and an inability to tolerate stress. Performing high-throughput RNA sequencing on aging stem cells, cytokine arrays, and functional assays, we identify an age-associated imbalance in epidermal Jak-Stat signaling that inhibits stem cell function. Collectively, this study reveals a role for the aging epidermis in the disruption of cytokine and stem cell homeostasis, suggesting that stem cell decline during aging may be part of broader tumor-suppressive mechanisms.
干细胞动态平衡的改变与机体衰老有关。然而，相关机制仍知之甚少。本研究报道了皮肤衰老过程中毛囊干细胞的新变化，包括数量增加、功能下降以及无法耐受应激。通过对衰老干细胞进行高通量 RNA 测序、细胞因子阵列和功能检测，我们发现表皮 Jak-Stat 信号通路的年龄相关失衡会抑制干细胞功能。综上所述，该研究揭示了衰老表皮在细胞因子和干细胞动态平衡破坏中的作用，表明衰老过程中干细胞的衰退可能是更广泛的肿瘤抑制机制的一部分。
