School of Nursing, Midwifery & Nutrition, James Cook University, Cairns, Queensland, Australia.
J Adv Nurs. 2013 Jul;69(7):1539-48. doi: 10.1111/jan.12012. Epub 2012 Sep 14.
To test the effect of a nurse-led intervention on weight gain in people with serious mental illness prescribed and taking second generation antipsychotic medication.
Weight gain and obesity has reached epidemic proportions in the general population with the prevalence of Metabolic Syndrome reaching 20-25% of the global population. People with serious mental illness are at even higher risk, particularly those taking second generation antipsychotic medication.
An experimental randomized controlled trial was undertaken.
The control group received a 12-week healthy lifestyle booklet. In addition to the booklet, the intervention group received weekly nutrition and exercise education, exercise sessions, and nurse support. Participants (n = 101) were assessed at baseline and 12 weeks. Data were collected between March 2008-December 2010. Seven outcome measures were used: body measurements included girth (cm), weight (kg), height (cm), and body mass index (kg/m(2) ); questionnaires included the medication compliance questionnaire, the Drug Attitude Inventory, the Liverpool University Neuroleptic Side Effect Rating Scale, and the Medical Outcomes Study Short Form 36. Differences in primary outcome measures between baseline and 12 weeks follow-up were compared between intervention and control groups using standard bi-variate statistical tests. The study was conducted between 2008-2010.
The analysis of outcome measures for the control group (n = 50) and intervention group (n = 51) was not statistically significant. There was a mean weight change of -0·74 kg at 12 weeks for the intervention group (n = 51), while the control group (n = 50) had a mean weight change of -0·17 kg at 12 weeks.
The results were not statistically significant.
检验以护士为主导的干预对服用第二代抗精神病药物的严重精神疾病患者体重增加的影响。
体重增加和肥胖在普通人群中已达到流行程度，代谢综合征的患病率达到全球人口的 20-25%。严重精神疾病患者的风险更高，尤其是那些服用第二代抗精神病药物的患者。
进行了一项实验性随机对照试验。
对照组接受为期 12 周的健康生活方式手册。除了手册外，干预组还接受每周的营养和运动教育、运动课程和护士支持。参与者（n=101）在基线和 12 周时进行评估。数据收集于 2008 年 3 月至 2010 年 12 月期间。使用了七种结果衡量标准：身体测量包括周长（cm）、体重（kg）、身高（cm）和体重指数（kg/m²）；问卷包括药物依从性问卷、药物态度量表、利物浦大学神经阻滞剂副作用量表和医疗结局研究短表 36。使用标准双变量统计检验比较干预组和对照组在基线和 12 周随访期间主要结果衡量标准的差异。该研究于 2008 年至 2010 年进行。
对对照组（n=50）和干预组（n=51）的结果衡量标准进行分析，结果无统计学意义。干预组（n=51）在 12 周时的体重变化平均为-0.74kg，而对照组（n=50）在 12 周时的体重变化平均为-0.17kg。
结果无统计学意义。
