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成人死亡与未来:2003-2007 年坦桑尼亚农村一项纵向研究中成人死因的特定原因分析

Adult deaths and the future: a cause-specific analysis of adult deaths from a longitudinal study in rural Tanzania 2003-2007.

机构信息

Dodowa Health Research Centre, Accra Region, Ghana  Dangme West District Health Administration, Ghana Health Service, Dodowa, Ghana  Division of Epidemiology and Biostatistics, University of Witwatersrand, Johannesburg, South Africa  Ifakara Health Institute, Dar es salaam, Tanzania.

出版信息

Trop Med Int Health. 2012 Nov;17(11):1396-404. doi: 10.1111/j.1365-3156.2012.03080.x. Epub 2012 Sep 14.

Abstract

OBJECTIVES

To determine patterns and risk factors for cause-specific adult mortality in rural southern Tanzania.

METHODS

The study was a longitudinal open cohort and focused on adults aged 15-59 years between 2003 and 2007. Causes of deaths were ascertained by verbal autopsy (VA). Cox proportion hazards regression model was used to determine factors associated with cause-specific mortality over the 5-year period.

RESULTS

Thousand three hundred and fifty-two of 65 548 adults died, representing a crude adult mortality rate (AMR) of 7.3 per 1000 person years of observation (PYO). VA was performed for 1132 (84%) deaths. HIV/AIDS [231 (20.4%)] was the leading cause of death followed by malaria [150 (13.2%)]. AMR for communicable disease (CD) causes was 2.49 per 1000 PYO, 1.21 per 1000 PYO for non-communicable diseases (NCD) and 0.53 per 1000 PYO for accidents/injury causes. NCD deaths increased from 16% in 2003 to 24% in 2007. High level of education was associated with a reduction in the risk of dying from NCDs. Those with primary education (HR = 0.67, 95% CI: 0.49, 0.92) and with education beyond primary school (HR = 0.11, 95% CI: 0.02, 0.40) had lower mortality than those who had no formal education. Compared with local residents, in-migrants were 1.7 (95% CI: 1.37, 2.11) times more likely to die from communicable disease causes.

CONCLUSION

NCDs are increasing as a result of demographic and epidemiological transitions taking place in most African countries including Tanzania and require attention to prevent increased triple disease burden of CD, NCD and accident/injuries.

摘要

目的

确定坦桑尼亚南部农村地区特定原因成人死亡率的模式和危险因素。

方法

本研究为一项纵向开放队列研究,重点关注 2003 年至 2007 年间年龄在 15 至 59 岁的成年人。通过死因推断(VA)确定死亡原因。使用 Cox 比例风险回归模型确定 5 年内与特定原因死亡相关的因素。

结果

65548 名成年人中有 1352 人死亡,粗死亡率(AMR)为每 1000 人观察年(PYO)7.3 人。对 1132 例(84%)死亡进行了 VA。艾滋病毒/艾滋病[231(20.4%)]是主要死亡原因,其次是疟疾[150(13.2%)]。传染病(CD)原因的 AMR 为每 1000 PYO 2.49,非传染性疾病(NCD)为每 1000 PYO 1.21,事故/伤害原因每 1000 PYO 0.53。2003 年至 2007 年,NCD 死亡人数从 16%增加到 24%。高教育水平与降低 NCD 死亡风险相关。具有小学教育水平(HR = 0.67,95%CI:0.49,0.92)和超过小学教育水平(HR = 0.11,95%CI:0.02,0.40)的人比没有正规教育的人死亡率更低。与当地居民相比,移民的传染病死亡风险高 1.7 倍(95%CI:1.37,2.11)。

结论

由于包括坦桑尼亚在内的大多数非洲国家正在经历人口和流行病学转变,NCD 正在增加,需要注意预防 CD、NCD 和事故/伤害的三重疾病负担增加。

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