Department of Otorhinolaryngology, Head and Neck Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Oral Oncol. 2012 Nov;48(11):1101-5. doi: 10.1016/j.oraloncology.2012.08.007. Epub 2012 Sep 10.
Recent advances in indocyanine green (ICG) fluorescence imaging have enabled the visualization of the blood supply to tissues. For advanced head and neck cancer, intra-arterial chemotherapy has been applied for organ preservation and improvement of the prognosis. To identify the tumor-feeding artery, through which the intra-arterial chemotherapy should be administered, CT angiography has been shown to be useful. However, the precise evaluation for oral cancer patients depends on the oral environment, that is, whether they have been treated with dental metal.
To assess the feasibility of the ICG fluorescence technique during intra-arterial chemotherapy for advanced oral cancer.
Twenty-five patients with oral cancer who were treated by intra-arterial chemotherapy were included in this study. Conventional CT angiography followed by 5mg of ICG injection was performed to confirm the areas in which the drug had dispersed. Intra-arterial chemotherapy was administered at 75 mg/m(2) of CDDP. Additional information about the arteries feeding the tumors provided by ICG was evaluated.
Out of 25 cases, in 15 (56%) the blood supply to the cancer was clearly detected by CT angiography. Using the infrared ICG evaluation, the blood supply to the tumor was confirmed easily in all cases. The information obtained from fluorescence imaging was helpful for making decisions concerning the administration of chemo-agents for oral cancers.
ICG fluorescence imaging during intra-arterial chemotherapy compensated for the deficiencies of CT angiography, especially for oral cancer. ICG fluorescence provided us clearer and more useful information about the feeders to tumors.
吲哚菁绿（ICG）荧光成像的最新进展使得组织血供可视化成为可能。对于晚期头颈部癌症，已经应用了动脉内化疗来进行器官保存和改善预后。为了识别肿瘤供血动脉，通过该动脉给予动脉内化疗，CT 血管造影已被证明是有用的。然而，对于口腔癌患者的精确评估取决于口腔环境，即他们是否接受过牙科金属治疗。
评估 ICG 荧光技术在晚期口腔癌动脉内化疗中的可行性。
本研究纳入了 25 例接受动脉内化疗的口腔癌患者。进行常规 CT 血管造影，然后注射 5mgICG，以确认药物扩散的区域。给予 75mg/m2的 CDDP 进行动脉内化疗。评估 ICG 提供的肿瘤供血动脉的额外信息。
在 25 例病例中，15 例（56%）通过 CT 血管造影清楚地检测到癌症的血液供应。使用近红外 ICG 评估，在所有病例中都容易确认肿瘤的血液供应。荧光成像获得的信息有助于决定对口腔癌进行化疗药物的给药。
在动脉内化疗期间进行 ICG 荧光成像弥补了 CT 血管造影的不足，特别是对于口腔癌。ICG 荧光为我们提供了更清晰、更有用的肿瘤供血信息。
