Grupo Reproducción, Facultad de Medicina. Universidad de Antioquia. Medellín, Colombia.
Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov;87(4-5):127-34. doi: 10.1016/j.plefa.2012.08.003. Epub 2012 Sep 10.
Preeclampsia is a disorder of pregnancy, characterized by hypertension and proteinuria after 20 weeks of gestation. Here, we evaluated the role of aspirin triggered-lipoxin A(4) (ATL, 15-epi-LXA(4)) on the modulation of the adhesion of human polymorphonuclear neutrophils (PMN) to endothelial cells initiated by preeclamptic plasma.
Plasma from preeclamptic, normotensive pregnant, and non-pregnant women were analyzed for factors involved in regulating angiogenesis, inflammation and lipid peroxidation. Plasma from preeclamptic women was added to human umbilical vein endothelial cells, and the adhesion of PMN (incubated with or without ATL) to cells was evaluated.
Preeclampsia was associated with some augmented anti-angiogenic, oxidative and pro-inflammatory markers, as well as increasing human PMN-endothelial cell adhesion. This cell adhesion was reduced when human PMN were incubated with ATL prior to addition to endothelial monolayers.
Our results are the starting point for further research on the efficacy and rational use of aspirin in preeclampsia.
子痫前期是一种妊娠疾病，其特征是在妊娠 20 周后出现高血压和蛋白尿。在这里，我们评估了阿司匹林触发的脂氧素 A（ATL，15-epi-LXA（4））在调节由子痫前期血浆引发的人中性粒细胞（PMN）与内皮细胞的黏附中的作用。
分析子痫前期、正常血压孕妇和非孕妇的血浆中参与调节血管生成、炎症和脂质过氧化的因素。将来自子痫前期妇女的血浆添加到人脐静脉内皮细胞中，并评估PMN（孵育有或没有 ATL）与细胞的黏附。
子痫前期与一些增强的抗血管生成、氧化和促炎标志物以及增加的人PMN-内皮细胞黏附有关。当人PMN在用 ATL 孵育后添加到内皮单层中时，这种细胞黏附减少。
我们的结果是进一步研究阿司匹林在子痫前期中的疗效和合理应用的起点。
