Aass N, Kaasa S, Lund E, Kaalhus O, Heier M S, Fosså S D
Department of Medical Oncology and Radiotherapy, Norwegian Radium Hospital, Montebello, Oslo.
Br J Cancer. 1990 Jan;61(1):151-5. doi: 10.1038/bjc.1990.31.
In order to evaluate long-term somatic morbidity after treatment for testicular cancer 149 patients with NED greater than or equal to 3 years answered a questionnaire. The patients had been treated with surgery only (32 patients, radiotherapy only (39 patients), cisplatin-based chemotherapy plus surgery (46 patients) or chemotherapy plus radiotherapy with or without surgery (32 patients). Raynaud-like phenomena were the most frequent side-effect occurring significantly more often after cisplatin-based chemotherapy than after surgery or radiotherapy (33/72 patients versus 5/68 patients). Peripheral sensory 'neuropathy' was reported by 18% of all the patients. Seventeen per cent and 11% complained of pulmonary symptoms and auditory symptoms, respectively. Gastrointestinal side-effects were more frequent after any type of cytotoxic therapy than after surgery only (34/47 patients versus 5/22 patients). Twenty-six patients had fathered children after treatment. About 80% of the patients were in full time wage-earning activity when they answered the questionnaire. In conclusion, 3-7 years after treatment for testicular cancer, 30-50% of the patients had minor somatic complaints whereas serious side-effects seldom occurred.
为了评估睾丸癌治疗后的长期躯体疾病情况，149例无疾病证据（NED）达3年及以上的患者回答了一份问卷。这些患者仅接受了手术治疗（32例）、仅接受了放射治疗（39例）、以顺铂为基础的化疗加手术（46例）或化疗加放射治疗（无论是否接受手术，32例）。雷诺样现象是最常见的副作用，在以顺铂为基础的化疗后出现的频率明显高于手术或放射治疗后（72例患者中有33例，而68例患者中有5例）。所有患者中有18%报告有周围感觉“神经病变”。分别有17%和11%的患者抱怨有肺部症状和听觉症状。与仅接受手术相比，任何类型的细胞毒性治疗后胃肠道副作用更常见（化疗后47例患者中有34例，而手术组22例患者中有5例）。26例患者在治疗后生育了子女。在回答问卷时，约80%的患者从事全职有薪工作。总之，在睾丸癌治疗后3至7年，30%至50%的患者有轻微的躯体不适，而严重副作用很少发生。
