Radboud University Nijmegen Medical Centre, Clinical Physics Laboratory, Nijmegen, The Netherlands.
Ultrasound Med Biol. 2012 Nov;38(11):1998-2006. doi: 10.1016/j.ultrasmedbio.2012.07.004. Epub 2012 Sep 10.
To noninvasively estimate the blood pressure continuously in the common carotid artery (CCA), we obtained the distension waveform of the CCA from seven healthy volunteers and 20 hypertensive patients using radio-frequency ultrasound. Consequently, it was calibrated by the mean and diastolic pressure measured in the finger artery and compared with applanation tonometry, calibrated using the systolic and diastolic pressure in the brachial artery. The mean difference in estimating the mean blood pressure was 0.3 mm Hg (limits of agreement: -11.7 to 12.3 mm Hg). In estimating the systolic blood pressure, the mean difference was 8.0 mm Hg (limits of agreement: -29.8 to 45.8 mm Hg) and showed increasing variation with blood pressure. The systolic blood pressure values can be expected between 0.83 and 1.35 times the control method. In this study, we obtained proof-of-principle for noninvasively measuring blood pressure in the CCA using continuous finger blood pressure monitoring. This opens the way to estimating location specific arterial stiffness and intra-plaque elasticity.
为了无创地连续估计颈总动脉（CCA）的血压，我们使用射频超声从 7 名健康志愿者和 20 名高血压患者中获得了 CCA 的膨胀波形。随后，通过手指动脉测量的平均压和舒张压进行校准，并与使用肱动脉的收缩压和舒张压校准的触诊法进行比较。估计平均血压的平均差值为 0.3mmHg（一致性界限：-11.7 至 12.3mmHg）。在估计收缩压时，平均差值为 8.0mmHg（一致性界限：-29.8 至 45.8mmHg），且随着血压的升高而变化。收缩压值可预期为对照方法的 0.83 至 1.35 倍。在这项研究中，我们使用连续手指血压监测无创测量 CCA 血压的原理得到了验证。这为估计特定部位动脉僵硬和斑块内弹性开辟了道路。
