Toxicology Services, 6 Stocken Hall Mews, Stretton, Oakham, Rutland LE15 7RL, UK.
Regul Toxicol Pharmacol. 2012 Nov;64(2):296-304. doi: 10.1016/j.yrtph.2012.08.020. Epub 2012 Sep 3.
Intensive study of the natural asbestiform minerals that cause human diseases, and the consequent understanding of their hazardous characteristics, has enabled the development of manufactured fibres whose physical and/or chemical properties, in particular as they relate to biopersistence, have been adjusted to minimize possible harm to health. A strong driver for the developmentof new high temperature insulation materials wasthe perception of the toxicity of refractory ceramic fibres (RCF)and their classification in the EU as a category 2 carcinogen under Directive 67/548/EEC. Such classification carries with it the requirement for substitution by less hazardous materials. This paper focuses on the development of alkaline earth silicate (AES) wools as a new class of high temperature insulation with the capability of such substitution in a number of applications. These wools have only a low potential to cause harm because they do not persist in lung tissue once deposited, and have produced minimal effects in experimental test systems. AES wools are increasingly being used in a wide range of high temperature applications.
对导致人类疾病的天然石棉状矿物质进行深入研究,并由此了解其有害特征,使得能够开发出人造纤维,这些纤维的物理和/或化学特性,特别是与其生物持久性有关的特性,经过调整以将对健康的可能危害降到最低。开发新型高温隔热材料的一个主要驱动力是认识到耐火陶瓷纤维(RCF)的毒性,并根据 67/548/EEC 指令将其归类为欧盟 2 类致癌物质。这种分类要求用危害较小的材料替代。本文重点介绍了作为一类新型高温隔热材料的碱土硅酸盐(AES)羊毛的开发,这种羊毛在许多应用中具有替代的能力。这些羊毛由于一旦沉积在肺组织中就不会持久存在,因此只有低的潜在危害,并且在实验测试系统中产生的影响最小。AES 羊毛越来越多地被用于各种高温应用。