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泛基因组学——一种改良工业起始培养物和益生菌的途径。

Pangenomics--an avenue to improved industrial starter cultures and probiotics.

机构信息

CED-Discovery, Chr Hansen A/S, 10-12 Bøge Allé, DK2970, Hørsholm, Denmark.

出版信息

Curr Opin Biotechnol. 2013 Apr;24(2):187-91. doi: 10.1016/j.copbio.2012.08.009. Epub 2012 Sep 10.

Abstract

With the dramatic reductions in the cost and time involved in DNA sequencing, a new approach to characterisation of bacteria is emerging. It is based on a comparison of complete genome sequences of a number of members of the same species (pangenomics). Pangenomics opens an array of new opportunities for understanding and improving industrial starter cultures and probiotics. These include understanding the formation of texture and flavour in dairy products, understanding the functionality of probiotics as well as providing information that can be used for strain screening, strain improvement, safety assessments and process improvements.

摘要

随着 DNA 测序成本和时间的大幅降低,一种新的细菌特征描述方法正在出现。它基于对同一物种的多个成员的完整基因组序列进行比较(泛基因组学)。泛基因组学为理解和改进工业起始培养物和益生菌开辟了一系列新的机会。这些包括了解乳制品质地和风味的形成,了解益生菌的功能,以及提供可用于菌株筛选、菌株改良、安全性评估和工艺改进的信息。

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