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免疫功能低下患者播散性旋毛虫病的挽救治疗：皮下伊维菌素治疗成功。

Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin.

机构信息

Hospital Santa Luzia, Brasília, Brazil.

出版信息

Braz J Infect Dis. 2012 Sep-Oct;16(5):479-81. doi: 10.1016/j.bjid.2012.08.008. Epub 2012 Sep 10.

DOI:10.1016/j.bjid.2012.08.008
PMID:22975175
Abstract

Disseminated strongyloidiasis is a disease with high mortality rate, especially in immunocompromised individuals. Paralytic ileus and intestinal malabsorption are frequent symptoms caused by this severe disease. As there are no licensed parenteral anthelmintic drugs for human use, off-label formulations are often used in the treatment of this disease. In this case report, the use of subcutaneous ivermectin is described as a successful therapy for this life-threatening infection.

摘要

播散性旋毛虫病是一种死亡率很高的疾病，尤其是在免疫功能低下的个体中。这种严重疾病常导致麻痹性肠梗阻和肠道吸收不良等症状。由于没有获得许可的人体用驱虫药物，因此通常使用标签外制剂治疗这种疾病。在本病例报告中，描述了皮下使用伊维菌素作为这种危及生命的感染的成功治疗方法。

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Salvage treatment of disseminated strongyloidiasis in an immunocompromised patient: therapy success with subcutaneous ivermectin.免疫功能低下患者播散性旋毛虫病的挽救治疗：皮下伊维菌素治疗成功。
Braz J Infect Dis. 2012 Sep-Oct;16(5):479-81. doi: 10.1016/j.bjid.2012.08.008. Epub 2012 Sep 10.
2
Treatment of human disseminated strongyloidiasis with a parenteral veterinary formulation of ivermectin.用伊维菌素的一种肠胃外兽用制剂治疗人类播散性类圆线虫病。
Clin Infect Dis. 2005 Jul 1;41(1):e5-8. doi: 10.1086/430827. Epub 2005 May 11.
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Parenteral administration of ivermectin in a patient with disseminated strongyloidiasis.伊维菌素经肠胃外途径给药治疗一名播散性类圆线虫病患者。
Am J Trop Med Hyg. 2005 Nov;73(5):911-4.
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Case report: failure of subcutaneous ivermectin in treating Strongyloides hyperinfection.病例报告：皮下注射伊维菌素治疗类圆线虫重度感染失败
Am J Trop Med Hyg. 2008 Dec;79(6):853-5.
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[Subcutaneous ivermectin in disseminated strongyloidiasis: A veterinary preparation authorised for human use].[皮下注射伊维菌素治疗播散性类圆线虫病：一种获批准用于人类的兽用制剂]
Med Clin (Barc). 2016 Apr 15;146(8):376-7. doi: 10.1016/j.medcli.2015.10.008. Epub 2015 Dec 2.
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Subcutaneous ivermectin as a safe salvage therapy in Strongyloides stercoralis hyperinfection syndrome: a case report.皮下注射伊维菌素作为粪类圆线虫重度感染综合征的一种安全挽救疗法：一例报告
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Disseminated Strongyloides stercoralis infection with a cutaneous presentation in an immunosuppressed patient.一名免疫抑制患者出现皮肤表现的播散性粪类圆线虫感染。
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Strongyloides disseminated infection successfully treated with parenteral ivermectin: case report with drug concentration measurements and review of the literature.伊维菌素静脉给药成功治疗播散性旋毛虫病：病例报告及文献复习。
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Worms on the brain: fatal meningoencephalitis from disseminated strongyloides infection.脑中的蠕虫：播散性类圆线虫感染导致的致命性脑膜脑炎
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[Fulminant strongyloidiasis successfully treated by subcutaneous ivermectin: an autopsy case].[皮下注射伊维菌素成功治疗暴发性类圆线虫病：一例尸检病例]
Rinsho Shinkeigaku. 2008 Jan;48(1):30-5. doi: 10.5692/clinicalneurol.48.30.

引用本文的文献

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Fatal strongyloidiasis after corticosteroid therapy for presumed chronic obstructive pulmonary disease.因疑似慢性阻塞性肺疾病接受皮质类固醇治疗后发生的致命性类圆线虫病。
JMM Case Rep. 2018 Sep 11;5(9):e005165. doi: 10.1099/jmmcr.0.005165. eCollection 2018 Sep.
2
Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy.病例报告：在接受体外膜肺氧合和持续肾脏替代治疗的患者中，伊维菌素和阿苯达唑的血浆浓度。
Am J Trop Med Hyg. 2018 Nov;99(5):1194-1197. doi: 10.4269/ajtmh.18-0487.
3
Successful use of subcutaneous ivermectin for the treatment of hyperinfection in the setting of small bowel obstruction and paralytic ileus in the immunocompromised population.
在免疫功能低下人群中，成功使用皮下注射伊维菌素治疗小肠梗阻和麻痹性肠梗阻情况下的重度感染。
BMJ Case Rep. 2018 Jun 4;2018:bcr-2017-223138. doi: 10.1136/bcr-2017-223138.
4
Human infection with Strongyloides stercoralis and other related Strongyloides species.人类感染粪类圆线虫及其他相关类圆线虫物种。
Parasitology. 2017 Mar;144(3):263-273. doi: 10.1017/S0031182016000834. Epub 2016 May 16.