病例报告：在接受体外膜肺氧合和持续肾脏替代治疗的患者中，伊维菌素和阿苯达唑的血浆浓度。
Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy.
机构信息
Department of Medicine, University of British Columbia, Vancouver, Canada.
University of Nebraska Medical Centre, Omaha, Nebraska.
出版信息
Am J Trop Med Hyg. 2018 Nov;99(5):1194-1197. doi: 10.4269/ajtmh.18-0487.
Abstract
Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extracorporeal membrane oxygenation and continuous renal replacement therapy in a patient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.
摘要
播散性旋毛虫病即使经过口服阿苯达唑和皮下伊维菌素（IVM）治疗，也常常致命。在此，我们报道了一例播散性旋毛虫病患者在接受皮下 IVM 和鼻胃管阿苯达唑治疗的同时，接受体外膜肺氧合和连续肾脏替代治疗后，血浆中 IVM 和阿苯达唑砜浓度升高的情况。尽管药物血浆浓度升高，但在治疗 2 周后，仍在气管内吸出物中检测到活丝虫幼虫。
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