酵母Ccr4-not复合体对延伸的调控。
The control of elongation by the yeast Ccr4-not complex.
作者信息
Reese Joseph C
机构信息
Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802, USA.
出版信息
Biochim Biophys Acta. 2013 Jan;1829(1):127-33. doi: 10.1016/j.bbagrm.2012.09.001. Epub 2012 Sep 10.
Abstract
The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation. Understanding its mechanisms of action has been difficult due to the size of the complex and the fact that it regulates mRNAs and proteins at many levels in both the cytoplasm and the nucleus. Recently, biochemical and genetic studies on the yeast Ccr4-Not complex have revealed insights into its role in promoting elongation by RNA polymerase II. This review will describe what is known about the Ccr4-Not complex in regulating transcription elongation and its possible collaboration with other factors traveling with RNAPII across genes. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
摘要
Ccr4-Not复合物是一种高度保守的九亚基蛋白质复合物，几乎涉及基因调控的各个方面，包括转录、mRNA降解与质量控制、RNA输出、翻译抑制和蛋白质泛素化。由于该复合物的规模以及它在细胞质和细胞核中多个水平上对mRNA和蛋白质进行调控这一事实，了解其作用机制一直颇具难度。最近，针对酵母Ccr4-Not复合物的生化和遗传学研究揭示了其在促进RNA聚合酶II延伸方面的作用。本综述将描述关于Ccr4-Not复合物在调控转录延伸方面的已知信息，以及它与其他伴随RNAPII跨越基因的因子可能存在的协作。本文是名为“RNA聚合酶II转录延伸”的特刊的一部分。
相似文献
1
The control of elongation by the yeast Ccr4-not complex.酵母Ccr4-not复合体对延伸的调控。
Biochim Biophys Acta. 2013 Jan;1829(1):127-33. doi: 10.1016/j.bbagrm.2012.09.001. Epub 2012 Sep 10.
2
Ccr4-Not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII.CCR4-NOT 复合体通过控制转录延伸受阻的 RNA 聚合酶 II 的泛素化和降解来维持基因组的完整性。
Genes Dev. 2019 Jun 1;33(11-12):705-717. doi: 10.1101/gad.322453.118. Epub 2019 Apr 4.
3
The Rpb4/7 module of RNA polymerase II is required for carbon catabolite repressor protein 4-negative on TATA (Ccr4-not) complex to promote elongation.RNA聚合酶II的Rpb4/7模块是使TATA盒上碳代谢物阻遏蛋白4阴性（Ccr4-not）复合物促进延伸所必需的。
J Biol Chem. 2014 Nov 28;289(48):33125-30. doi: 10.1074/jbc.C114.601088. Epub 2014 Oct 14.
4
Genome-Wide Mapping of Decay Factor-mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4.酵母中衰变因子与mRNA相互作用的全基因组图谱鉴定出营养响应转录本是去腺苷酸化酶Ccr4的作用靶点。
G3 (Bethesda). 2018 Jan 4;8(1):315-330. doi: 10.1534/g3.117.300415.
5
Ccr4-Not and TFIIS Function Cooperatively To Rescue Arrested RNA Polymerase II.Ccr4-Not与TFIIS协同作用以拯救停滞的RNA聚合酶II。
Mol Cell Biol. 2015 Jun 1;35(11):1915-25. doi: 10.1128/MCB.00044-15. Epub 2015 Mar 16.
6
The Regulatory Properties of the Ccr4-Not Complex.Ccr4-Not 复合物的调控特性。
Cells. 2020 Oct 29;9(11):2379. doi: 10.3390/cells9112379.
7
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis.Ccr4-not调节RNA聚合酶I转录，并将营养信号与核糖体RNA生物合成的控制联系起来。
PLoS Genet. 2015 Mar 27;11(3):e1005113. doi: 10.1371/journal.pgen.1005113. eCollection 2015 Mar.
8
The multifunctional Ccr4-Not complex directly promotes transcription elongation.多功能 Ccr4-Not 复合物直接促进转录延伸。
Genes Dev. 2011 Mar 15;25(6):581-93. doi: 10.1101/gad.2020911.
9
Genome wide expression analysis of the CCR4-NOT complex indicates that it consists of three modules with the NOT module controlling SAGA-responsive genes.CCR4-NOT复合物的全基因组表达分析表明，它由三个模块组成，其中NOT模块控制着对SAGA有反应的基因。
Mol Genet Genomics. 2008 Apr;279(4):323-37. doi: 10.1007/s00438-007-0314-1. Epub 2008 Jan 23.
10
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4.mRNA 降解因子 Xrn1 与 Ccr4 平行调节转录延伸。
Nucleic Acids Res. 2019 Oct 10;47(18):9524-9541. doi: 10.1093/nar/gkz660.
引用本文的文献
1
The effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT.效应蛋白PieF通过与真核生物CCR4-NOT结合来调节mRNA稳定性。
mSphere. 2025 Jan 28;10(1):e0089124. doi: 10.1128/msphere.00891-24. Epub 2024 Dec 19.
2
Characterization of BioID tagging systems in budding yeast and exploring the interactome of the Ccr4-Not complex.酵母中 BioID 标记系统的特征分析及 Ccr4-Not 复合物互作组的探索。
G3 (Bethesda). 2024 Nov 6;14(11). doi: 10.1093/g3journal/jkae221.
3
Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability.破坏哺乳动物 Ccr4-Not 复合物会导致转录介导的基因组不稳定性。
Cells. 2023 Jul 17;12(14):1868. doi: 10.3390/cells12141868.
4
New roles for elongation factors in RNA polymerase II ubiquitylation and degradation.延伸因子在 RNA 聚合酶 II 泛素化和降解中的新作用。
Biochim Biophys Acta Gene Regul Mech. 2023 Sep;1866(3):194956. doi: 10.1016/j.bbagrm.2023.194956. Epub 2023 Jun 17.
5
Enhanced gene regulation by cooperation between mRNA decay and gene transcription.通过 mRNA 降解和基因转录的协同作用增强基因调控。
Biochim Biophys Acta Gene Regul Mech. 2023 Jun;1866(2):194910. doi: 10.1016/j.bbagrm.2023.194910. Epub 2023 Jan 30.
6
DEF1: Much more than an RNA polymerase degradation factor.DEF1：不仅仅是 RNA 聚合酶降解因子。
DNA Repair (Amst). 2021 Nov;107:103202. doi: 10.1016/j.dnarep.2021.103202. Epub 2021 Aug 5.
7
The total mRNA concentration buffering system in yeast is global rather than gene-specific.酵母中的总mRNA浓度缓冲系统是全局性的，而非基因特异性的。
RNA. 2021 Oct;27(10):1281-1290. doi: 10.1261/rna.078774.121. Epub 2021 Jul 16.
8
The Regulatory Properties of the Ccr4-Not Complex.Ccr4-Not 复合物的调控特性。
Cells. 2020 Oct 29;9(11):2379. doi: 10.3390/cells9112379.
9
Overexpression of VIRE2-INTERACTING PROTEIN2 in Arabidopsis regulates genes involved in Agrobacterium-mediated plant transformation and abiotic stresses.在拟南芥中过表达 VIRE2-INTERACTING PROTEIN2 调控农杆菌介导的植物转化和非生物胁迫相关基因。
Sci Rep. 2019 Sep 18;9(1):13503. doi: 10.1038/s41598-019-49590-3.
10
Role of the Citrus sinensis RNA deadenylase CsCAF1 in citrus canker resistance.柑橘 RNA 去腺苷酸化酶 CsCAF1 在柑橘溃疡病抗性中的作用。
Mol Plant Pathol. 2019 Aug;20(8):1105-1118. doi: 10.1111/mpp.12815. Epub 2019 May 21.
本文引用的文献
1
SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation.SPT5影响mRNA降解速率，并与CCR4发生物理相互作用，但不控制mRNA去腺苷酸化。
Am J Mol Biol. 2012 Jan;2(1):11-20. doi: 10.4236/ajmb.2012.21002.
2
Genome-wide nucleosome specificity and directionality of chromatin remodelers.染色质重塑因子的全基因组核小体特异性和方向性。
Cell. 2012 Jun 22;149(7):1461-73. doi: 10.1016/j.cell.2012.04.036.
3
Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4.Yap1 转录因子的蛋白水解降解受亚细胞定位和 E3 泛素连接酶 Not4 的调节。
J Biol Chem. 2012 Aug 3;287(32):26796-805. doi: 10.1074/jbc.M112.384719. Epub 2012 Jun 15.
4
R loops: from transcription byproducts to threats to genome stability.R 环：从转录副产物到基因组稳定性的威胁。
Mol Cell. 2012 Apr 27;46(2):115-24. doi: 10.1016/j.molcel.2012.04.009.
5
Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction.氧化应激诱导的核质易位是 Not4 依赖性细胞周期蛋白 C 降解所必需的。
J Cell Sci. 2012 Feb 15;125(Pt 4):1015-26. doi: 10.1242/jcs.096479. Epub 2012 Mar 15.
6
Ccr4-Not complex: the control freak of eukaryotic cells.CCR4-Not 复合物：真核细胞的控制狂。
Crit Rev Biochem Mol Biol. 2012 Jul-Aug;47(4):315-33. doi: 10.3109/10409238.2012.667214. Epub 2012 Mar 15.
7
Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae.在酿酒酵母中，介体在调节 Pol II 延伸和核小体位移中的作用。
Genetics. 2012 May;191(1):95-106. doi: 10.1534/genetics.111.135806. Epub 2012 Feb 29.
8
A nexus for gene expression-molecular mechanisms of Spt5 and NusG in the three domains of life.基因表达枢纽——古菌、细菌和真核生物中 Spt5 和 NusG 的分子机制
J Mol Biol. 2012 Mar 16;417(1-2):13-27. doi: 10.1016/j.jmb.2012.01.031. Epub 2012 Jan 27.
9
Measurement of genome-wide RNA synthesis and decay rates with Dynamic Transcriptome Analysis (DTA).利用动态转录组分析（DTA）测量全基因组 RNA 的合成和降解速率。
Bioinformatics. 2012 Mar 15;28(6):884-5. doi: 10.1093/bioinformatics/bts052. Epub 2012 Jan 28.
10
New clues to understand the role of THO and other functionally related factors in mRNP biogenesis.了解THO及其他功能相关因子在mRNA核糖核蛋白体生物发生中作用的新线索。
Biochim Biophys Acta. 2012 Jun;1819(6):514-20. doi: 10.1016/j.bbagrm.2011.11.012. Epub 2011 Dec 20.
Zotero 插件