酵母Ccr4-not复合体对延伸的调控。
The control of elongation by the yeast Ccr4-not complex.
作者信息
Reese Joseph C
机构信息
Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802, USA.
出版信息
Biochim Biophys Acta. 2013 Jan;1829(1):127-33. doi: 10.1016/j.bbagrm.2012.09.001. Epub 2012 Sep 10.
The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation. Understanding its mechanisms of action has been difficult due to the size of the complex and the fact that it regulates mRNAs and proteins at many levels in both the cytoplasm and the nucleus. Recently, biochemical and genetic studies on the yeast Ccr4-Not complex have revealed insights into its role in promoting elongation by RNA polymerase II. This review will describe what is known about the Ccr4-Not complex in regulating transcription elongation and its possible collaboration with other factors traveling with RNAPII across genes. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
Ccr4-Not复合物是一种高度保守的九亚基蛋白质复合物，几乎涉及基因调控的各个方面，包括转录、mRNA降解与质量控制、RNA输出、翻译抑制和蛋白质泛素化。由于该复合物的规模以及它在细胞质和细胞核中多个水平上对mRNA和蛋白质进行调控这一事实，了解其作用机制一直颇具难度。最近，针对酵母Ccr4-Not复合物的生化和遗传学研究揭示了其在促进RNA聚合酶II延伸方面的作用。本综述将描述关于Ccr4-Not复合物在调控转录延伸方面的已知信息，以及它与其他伴随RNAPII跨越基因的因子可能存在的协作。本文是名为“RNA聚合酶II转录延伸”的特刊的一部分。
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