Department of Neurology, School of Medicine, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic.
Exp Brain Res. 2012 Nov;223(2):251-7. doi: 10.1007/s00221-012-3255-9. Epub 2012 Sep 14.
We studied whether one session of high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over either the right or left dorsolateral prefrontal cortex would induce any measurable changes in the Tower of London spatial planning task performance in patients with Parkinson's disease (PD). Ten patients with PD (with no dementia and/or depression) entered the randomized, sham-stimulation-controlled study with a crossover design. Active and placebo rTMS were applied over either the left or the right dorsolateral prefrontal cortex (in four separate sessions) in each patient. The order of sessions was randomized. The Tower of London task was performed prior to and immediately after each appropriate session. The "total problem-solving time" was our outcome measure. Only active rTMS of the right dorsolateral prefrontal cortex induced significant enhancement of the total problem-solving time, p = 0.038. Stimulation of the left prefrontal cortex or sham stimulations induced no significant effects. Only rTMS applied over the right dorsolateral prefrontal cortex induced positive changes in the spatial planning task performance in PD, which further supports the results of functional imaging studies indicating the causal engagement of the right-sided hemispheric structures in solving the task in this patient population.
我们研究了单次高频重复经颅磁刺激（rTMS）应用于右侧或左侧背外侧前额叶是否会导致帕金森病（PD）患者的伦敦塔空间规划任务表现有任何可测量的变化。10 名无痴呆和/或抑郁的 PD 患者进入了一项具有交叉设计的随机、假刺激对照研究。每位患者在左侧或右侧背外侧前额叶（分四个单独的疗程）接受活性和安慰剂 rTMS。疗程的顺序是随机的。在每个适当的疗程前后进行伦敦塔任务。我们的结果衡量标准是“总解决问题时间”。只有右侧背外侧前额叶的活性 rTMS 可显著提高总解决问题时间，p = 0.038。左侧前额叶刺激或假刺激均未引起显著影响。只有右侧背外侧前额叶的 rTMS 可使 PD 患者的空间规划任务表现产生积极变化，这进一步支持了功能成像研究的结果，表明右侧半球结构在解决该患者群体中的任务时的因果作用。
