夜班工作职业暴露矩阵与健康中国女性尿液中 6-硫酸褪黑素水平。
Nightshift work job exposure matrices and urinary 6-sulfatoxymelatonin levels among healthy Chinese women.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
出版信息
Scand J Work Environ Health. 2012 Nov;38(6):553-9. doi: 10.5271/sjweh.3322. Epub 2012 Sep 13.
OBJECTIVE
Six-sulfatoxymelatonin (aMT6s) is a primary urinary metabolite of melatonin. We examined the association between aMT6s levels and shift work estimated by a job exposure matrix (JEM) among healthy participants of the Shanghai Women's Health Study.
METHODS
Creatinine-adjusted aMT6s levels were measured in the urine samples of 300 women and related to JEM shift work categories.
RESULTS
Adjusted geometric means of aMT6s levels from urine samples collected before 08:00 hours were lower among persons holding nighttime shift work jobs. The adjusted aMT6s levels (ng/mg creatinine) were 8.36 [95% confidence intervals (95% CI) 4.47-15.6], 6.37 (95% CI 3.53-11.5), 6.20 (95% CI 3.33-11.5), 3.81 (95% CI 2.02-7.19), and 3.70 (95% CI 1.92-7.11) from the lowest (never held a shift work job) to the highest (current job likely involved all-night shift work) shift work JEM scores (P=0.05).
CONCLUSION
Our results indicate that nightshift work JEM scores were significantly and inversely associated with aMT6s levels in early morning spot urine samples collected between 07:00-08:00 hours.
目的
6-硫酸褪黑素（aMT6s）是褪黑素的主要尿代谢产物。我们研究了在上海女性健康研究中，健康参与者的 JEM（工作暴露矩阵）估计的轮班工作与 aMT6s 水平之间的关系。
方法
在 300 名女性的尿液样本中测量了经肌酐调整的 aMT6s 水平，并将其与 JEM 轮班工作类别相关联。
结果
在 08:00 小时之前采集的尿液样本中，从事夜班工作的人 aMT6s 水平的调整后几何平均值较低。调整后的 aMT6s 水平（ng/mg 肌酐）分别为 8.36（95%置信区间[95%CI]为 4.47-15.6）、6.37（95%CI 为 3.53-11.5）、6.20（95%CI 为 3.33-11.5）、3.81（95%CI 为 2.02-7.19）和 3.70（95%CI 为 1.92-7.11），最低（从未从事轮班工作）到最高（当前工作可能涉及通宵轮班工作）JEM 得分（P=0.05）。
结论
我们的结果表明，夜班 JEM 得分与凌晨 07:00-08:00 之间采集的晨尿样本中的 aMT6s 水平呈显著负相关。
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