Vahid Sepideh, Dashti-Khavidaki Simin, Ahmadi Farrokhlegha, Amini Mohsen, Salehi Surmaghi Mohammad Hosein
Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Kidney Dis. 2012 Sep;6(5):350-4.
Increased plasma nitric oxide concentration has been supposed as one of the possible mechanisms of bleeding tendency in patients who suffer chronic kidney disease. Nitric oxide-scavenging properties have been reported with some Achillea species. This study was designed to find any possible effect of Achillea millefolium on plasma nitric oxide concentration in these patients.
Thirty-one chronic kidney disease patients were included in this randomized controlled trial, of whom16 received 1.5 g of powdered A millefolium flower 3 days a week for 2 months, and 15 received placebo for the same period. Plasma samples were collected before and after the study period to estimate the effect of A millefolium on plasma nitric oxide metabolites (nitrite and nitrate).
Although not statistically significant, plasma nitrite and nitrate concentrations decreased after 2 months' administration of A millefolium (0.82 ± 0.51 µmol/L to 0.63 ± 0.42 µmol/L and 50.55 ± 17.92 µmol/L to 44.09 ± 17.49 µmole/L, respectively). These concentrations were slightly increased in the placebo group after the study period.
Countercurrent to the placebo group, plasma nitric oxide metabolites were marginally decreased after A millefolium administration in chronic kidney disease patients. Higher doses or longer duration of plant administration may make these changes more significant.
血浆一氧化氮浓度升高被认为是慢性肾病患者出血倾向的可能机制之一。已有报道某些蓍草属植物具有清除一氧化氮的特性。本研究旨在探究千叶蓍对这些患者血浆一氧化氮浓度的任何可能影响。
31例慢性肾病患者纳入本随机对照试验，其中16例患者每周3天服用1.5克千叶蓍花粉末，持续2个月，15例患者在同一时期服用安慰剂。在研究期前后采集血浆样本，以评估千叶蓍对血浆一氧化氮代谢产物（亚硝酸盐和硝酸盐）的影响。
尽管无统计学意义，但服用千叶蓍2个月后，血浆亚硝酸盐和硝酸盐浓度有所下降（分别从0.82±0.51微摩尔/升降至0.63±0.42微摩尔/升，从50.55±17.92微摩尔/升降至44.09±17.49微摩尔/升）。研究期后，安慰剂组的这些浓度略有升高。
与安慰剂组相反，慢性肾病患者服用千叶蓍后，血浆一氧化氮代谢产物略有下降。更高剂量或更长时间服用该植物可能会使这些变化更显著。
