Department of Biotechnology, Genetics and Cell Biology, State University of Maringá, Avenida Colombo 5790, Bloco H67 (11), Jardim Universitário, 87020-900 Maringá, PR, Brazil.
Federal Technological University of Paraná, Rua Marcílio Dias 635, 86812-460 Apucarana, PR, Brazil.
Evid Based Complement Alternat Med. 2013;2013:893050. doi: 10.1155/2013/893050. Epub 2013 Dec 29.
The investigation of traditionally used medicinal plants is valuable both as a source of potential chemotherapeutic drugs and as a measure of safety for the continued use of these medicinal plants. Achillea millefolium L. (AM) is an ancient remedial herb native to Europe that is used to treat wounds, gastrointestinal and hepatobiliary disorders, inflammation, headaches, and pain. Bauhinia forficata Link (BF), an Asiatic plant, is one of the most commonly used plants in folk medicine against diabetes. The aim of this study was to evaluate the cytotoxic and antimutagenic potential of aqueous extracts of AM and BF on bone marrow cells of Wistar rats treated in vivo. These plant extracts possess considerable antioxidant activity due to the presence of flavonoids and phenolic compounds. These compounds were determinants to noncytotoxic and antimutagenic/protective action of these plants, that reduced statistically the percentage of chromosomal alterations induced by the chemotherapeutic agent cyclophosphamide in simultaneous (AM, 68%; BF, 91%), pre- (AM, 68%; BF, 71%), and post-treatment (AM, 67%; BF, 95%). Therefore, the results of this study indicate that extracts of A. millefolium and B. forficata have antimutagenic potential and that their consumption can benefit the health of those using them as an alternative therapy.
对传统药用植物的研究具有重要意义，不仅可以作为潜在化疗药物的来源，还可以衡量这些药用植物持续使用的安全性。欧洲的古老草本植物蓍草（Achillea millefolium L.）被用于治疗伤口、胃肠道和肝胆疾病、炎症、头痛和疼痛。亚洲植物紫荆（Bauhinia forficata Link）是民间医学治疗糖尿病最常用的植物之一。本研究旨在评估 AM 和 BF 的水提物对体内接受治疗的 Wistar 大鼠骨髓细胞的细胞毒性和抗诱变潜力。这些植物提取物因含有类黄酮和酚类化合物而具有相当大的抗氧化活性。这些化合物是这些植物具有非细胞毒性和抗诱变/保护作用的决定因素，可显著降低化疗药物环磷酰胺诱导的染色体改变百分比，同时（AM，68%；BF，91%）、预处理（AM，68%；BF，71%）和后处理（AM，67%；BF，95%）。因此，本研究结果表明，蓍草和紫荆的提取物具有抗诱变潜力，它们的使用可以使将其作为替代疗法的使用者受益于健康。
