Nasu Hatsuko, Ikeda Akiko, Ogura Hiroyuki, Teruya Chikako, Koizumi Kei, Kinoshita Mana, Tsuchida Takashi, Baba Satoshi, Miura Katsutoshi, Takehara Yasuo, Sakahara Harumi
Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu City, Shizuoka Prefecture, 431-3192, Japan,
Breast Cancer. 2015 Sep;22(5):552-6. doi: 10.1007/s12282-012-0407-5. Epub 2012 Sep 14.
Diabetic mastopathy is a rare benign condition associated with long-standing diabetes mellitus and presents with breast lumps. This report describes two cases in which diffusion-weighted images (DWI) on magnetic resonance imaging were quite different from each other. In case 1, there were hyperintense lesions on DWI, and surgically removed specimens revealed ductitis with marked lymphocytic infiltration. In case 2, no abnormal intensity was depicted on DWI, and biopsy specimens showed dense stromal fibrosis with mild perivascular lymphocytic infiltration that corresponded to previous reports. Although it is reported that diabetic mastopathy is composed of dense fibrous tissue with low cellularity that results in no hyperintense lesion on DWI, in cases with marked lymphocytic infiltration, strong hyperintensity can be seen on DWI mimicking malignant breast tumors.
糖尿病性乳腺病是一种与长期糖尿病相关的罕见良性疾病,表现为乳腺肿块。本报告描述了两例磁共振成像上的扩散加权成像(DWI)彼此差异很大的病例。病例1中,DWI上有高信号病变,手术切除的标本显示为导管炎伴明显淋巴细胞浸润。病例2中,DWI上未显示异常信号,活检标本显示致密的间质纤维化伴轻度血管周围淋巴细胞浸润,与先前报道相符。尽管据报道糖尿病性乳腺病由细胞密度低的致密纤维组织组成,导致DWI上无高信号病变,但在有明显淋巴细胞浸润的病例中,DWI上可出现强烈高信号,类似恶性乳腺肿瘤。