Morgan M C, Weaver M G, Crowe J P, Abdul-Karim F W
Department of Pathology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Ohio, USA.
Mod Pathol. 1995 May;8(4):349-54.
Diabetic mastopathy is a distinct clinicopathologic entity with specific histopathologic characteristics which include keloidal fibrosis, epithelioid fibroblasts, widespread periductal/lobular lymphocytic infiltration, and widespread perivascular lymphocytic infiltration. We report the clinical and histopathologic breast tissue findings of 20 patients with diabetes mellitus as compared to 20 age-matched controls. The control patients also were matched for diseases other than diabetes mellitus. All patients with diabetes mellitus showed at least one of the histologic findings of diabetic mastopathy: 13 patients (65%) showed all four histopathologic characteristics; one patient showed three; one patient showed two; and five patients showed one feature. The 20 control patients did not demonstrate any of the four histopathologic features of diabetic mastopathy. We confirm previously reported findings of diabetic mastopathy presenting as palpable breast masses in insulin-dependent diabetics. However, we also suggest that diabetic mastopathy should be expanded to include the histopathologic findings characteristic in diabetic patients with nonpalpable mammographic abnormalities and breast tissue distant to the site of involvement by carcinoma.
糖尿病性乳腺病是一种具有特定组织病理学特征的独特临床病理实体，这些特征包括瘢痕疙瘩样纤维化、上皮样成纤维细胞、广泛的导管周围/小叶淋巴细胞浸润以及广泛的血管周围淋巴细胞浸润。我们报告了20例糖尿病患者与20例年龄匹配的对照者的临床及组织病理学乳腺组织检查结果。对照者也在除糖尿病以外的疾病方面进行了匹配。所有糖尿病患者均表现出至少一项糖尿病性乳腺病的组织学表现：13例患者（65%）表现出全部四项组织病理学特征；1例患者表现出三项；1例患者表现出两项；5例患者表现出一项特征。20例对照者未表现出糖尿病性乳腺病的四项组织病理学特征中的任何一项。我们证实了先前报道的胰岛素依赖型糖尿病患者中糖尿病性乳腺病表现为可触及乳腺肿块的发现。然而，我们还建议，糖尿病性乳腺病应扩大范围，将非触及性乳腺钼靶异常的糖尿病患者以及远离癌灶受累部位的乳腺组织中具有特征性的组织病理学表现包括在内。
