Department of Electrical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Lab Chip. 2012 Nov 7;12(21):4465-71. doi: 10.1039/c2lc40392g.
Cell-based sensing represents a new paradigm for performing direct and accurate detection of cell- or tissue-specific responses by incorporating living cells or tissues as an integral part of a sensor. Here we report a new magnetic cell-based sensing platform by combining magnetic sensors implemented in the complementary metal-oxide-semiconductor (CMOS) integrated microelectronics process with cardiac progenitor cells that are differentiated directly on-chip. We show that the pulsatile movements of on-chip cardiac progenitor cells can be monitored in a real-time manner. Our work provides a new low-cost approach to enable high-throughput screening systems as used in drug development and hand-held devices for point-of-care (PoC) biomedical diagnostic applications.
基于细胞的传感代表了一种新的范例,通过将活细胞或组织作为传感器的一个组成部分,直接且准确地检测细胞或组织特异性反应。在这里,我们通过将互补金属氧化物半导体(CMOS)集成电路微电子产品中实现的磁传感器与直接在芯片上分化的心脏祖细胞相结合,报告了一种新的基于磁的细胞传感平台。我们表明,可以实时监测芯片上心脏祖细胞的脉动运动。我们的工作为在药物开发和用于即时(PoC)生物医学诊断应用的手持式设备中使用的高通量筛选系统提供了一种新的低成本方法。