Madhavi R, Guntur M, Ghosh R, Ghosh P K
Department of Anthropology, University of Delhi, India.
Cancer Genet Cytogenet. 1990 Feb;44(2):203-7. doi: 10.1016/0165-4608(90)90048-f.
Cytogenetic analysis was performed in a young girl with breast carcinoma. The most important finding was the existence of double minute (dmin) chromosomes, besides other chromosomal abnormalities. Removal of the tumor resulted in reduction of chromosomal abnormalities in the leukocyte cultures repeated after 1 year, suggesting that the presence of tumor may elevate the frequency of chromosomal abnormalities. The presence of dmin chromosomes indicates that factors causing their presence in tumor cells may also operate in human leukocytes.
对一名患有乳腺癌的年轻女孩进行了细胞遗传学分析。最重要的发现是除了其他染色体异常外，还存在双微体（dmin）染色体。切除肿瘤导致1年后重复进行的白细胞培养中的染色体异常减少，这表明肿瘤的存在可能会提高染色体异常的频率。dmin染色体的存在表明导致其在肿瘤细胞中出现的因素也可能在人类白细胞中起作用。
