Mitra A B, Murty V V, Luthra U K
Cancer Genet Cytogenet. 1983 Feb;8(2):117-22. doi: 10.1016/0165-4608(83)90043-2.
Double-minute chromosomes (DMs) were observed in repeated samples in the leukocytes of a patient with a previous history of cervical carcinoma. The most interesting cytogenetic finding was the coexistence of DMs and a dicentric chromosome along with chromosome- and chromatid-type breaks and gaps. This observation suggests that DMs might originate through the breakage of existing chromosomes. The presence of DMs in leukocytes may also indicate the possibility that certain common agents cause DMs in tumor cells as well as in normal cells.
在一名有宫颈癌病史患者的白细胞重复样本中观察到双微体染色体（DMs）。最有趣的细胞遗传学发现是双微体染色体和双着丝粒染色体共存，同时伴有染色体型和染色单体型断裂及裂隙。这一观察结果表明，双微体染色体可能源于现有染色体的断裂。白细胞中双微体染色体的存在也可能意味着某些常见因素在肿瘤细胞和正常细胞中均可导致双微体染色体的形成。
