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1
NMT1 (N-myristoyltransferase 1).NMT1(N-肉豆蔻酰转移酶1)。
Atlas Genet Cytogenet Oncol Haematol. 2011 Jan 7;15(7):570-575. doi: 10.4267/2042/45997.
2
Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer.抑制 N-豆蔻酰转移酶活性可促进前列腺癌中雄激素受体的降解。
Prostate. 2024 Feb;84(3):254-268. doi: 10.1002/pros.24645. Epub 2023 Oct 31.
3
The role of N-myristoyltransferase 1 in tumour development.N-豆蔻酰转移酶 1 在肿瘤发生中的作用。
Ann Med. 2023 Dec;55(1):1422-1430. doi: 10.1080/07853890.2023.2193425.
4
N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level.N-肉豆蔻酰转移酶1通过调节病毒RNA表达水平增强人类免疫缺陷病毒复制。
Biochem Biophys Res Commun. 2015 Aug 7;463(4):988-93. doi: 10.1016/j.bbrc.2015.06.047. Epub 2015 Jun 11.
5
N-myristoyltransferase 1 is essential in early mouse development.N-肉豆蔻酰转移酶1在小鼠早期发育中至关重要。
J Biol Chem. 2005 May 13;280(19):18990-5. doi: 10.1074/jbc.M412917200. Epub 2005 Mar 7.
6
N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.N-肉豆蔻酰转移酶同工酶对1型人类免疫缺陷病毒的Gag和Nef表现出不同的特异性。
J Gen Virol. 2008 Jan;89(Pt 1):288-296. doi: 10.1099/vir.0.83412-0.
7
N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells.N-豆蔻酰转移酶-1 对于癌细胞中的溶酶体降解和 mTORC1 的激活是必需的。
Sci Rep. 2020 Jul 20;10(1):11952. doi: 10.1038/s41598-020-68615-w.
8
SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway.SPI1 介导 N-豆蔻酰转移酶 1 通过 PI3K/AKT/mTOR 通路促进胃癌进展。
Can J Gastroenterol Hepatol. 2023 Mar 17;2023:2021515. doi: 10.1155/2023/2021515. eCollection 2023.
9
N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.N-豆蔻酰基转移酶-1 缺乏会阻止 LAMTOR1 的豆蔻酰化,从而抑制膀胱癌的进展。
Cancer Lett. 2022 Mar 31;529:126-138. doi: 10.1016/j.canlet.2022.01.001. Epub 2022 Jan 6.
10
NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells.NMT1 维持 ICAM-1 以调节肿瘤细胞的黏附和迁移。
Cell Signal. 2023 Sep;109:110739. doi: 10.1016/j.cellsig.2023.110739. Epub 2023 Jun 1.

引用本文的文献

1
Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.间日疟原虫N-肉豆蔻酰转移酶与抑制剂IMP-1088的结构:探索用于抗疟治疗的NMT抑制剂
Acta Crystallogr F Struct Biol Commun. 2025 Jan 1;81(Pt 1):1-10. doi: 10.1107/S2053230X24011348.
2
Ternary structure of Plasmodium vivaxN-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173.恶性疟原虫 N-豆蔻酰转移酶与豆蔻酰辅酶 A 和抑制剂 IMP-0001173 的三元结构。
Acta Crystallogr F Struct Biol Commun. 2024 Oct 1;80(Pt 10):269-277. doi: 10.1107/S2053230X24008604. Epub 2024 Sep 18.
3
Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition.多组学分析鉴定出,通过抑制豆蔻酰化作用,氧化磷酸化可成为一种癌症易损性。
J Transl Med. 2024 May 7;22(1):431. doi: 10.1186/s12967-024-05150-6.
4
Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression.阻断 NMT1 的酶活性抑制 VILIP3 蛋白的 N-豆蔻酰化,从而抑制肝癌进展。
Signal Transduct Target Ther. 2023 Jan 9;8(1):14. doi: 10.1038/s41392-022-01248-9.
5
Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT).GCN5相关N-乙酰基转移酶(GNAT)的结构与功能多样性
Int J Mol Sci. 2016 Jun 28;17(7):1018. doi: 10.3390/ijms17071018.

本文引用的文献

1
The potential use of N-myristoyltransferase as a biomarker in the early diagnosis of colon cancer.N-豆蔻酰转移酶作为结肠癌早期诊断标志物的潜在用途。
Cancers (Basel). 2011 Mar 16;3(1):1372-82. doi: 10.3390/cancers3011372.
2
Myristoylation and membrane binding regulate c-Src stability and kinase activity.豆蔻酰化和膜结合调节 c-Src 的稳定性和激酶活性。
Mol Cell Biol. 2010 Sep;30(17):4094-107. doi: 10.1128/MCB.00246-10. Epub 2010 Jun 28.
3
The chemical toolbox for monitoring protein fatty acylation and prenylation.蛋白质酰化和类异戊二烯化的化学工具包。
Nat Chem Biol. 2010 Jul;6(7):498-506. doi: 10.1038/nchembio.388.
4
Monoclonal antibodies in the treatment of metastatic colorectal cancer: a review.单克隆抗体在转移性结直肠癌治疗中的应用:综述。
Clin Ther. 2010 Mar;32(3):437-53. doi: 10.1016/j.clinthera.2010.03.012.
5
Protein myristoylation in health and disease.健康与疾病中的蛋白质肉豆蔻酰化
J Chem Biol. 2010 Mar;3(1):19-35. doi: 10.1007/s12154-009-0032-8. Epub 2009 Nov 7.
6
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.T细胞受体信号传导的定量磷酸化蛋白质组学分析揭示了蛋白质-蛋白质相互作用的全系统调节。
Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007.
7
Evolving treatment of advanced colon cancer.晚期结肠癌的治疗进展
Annu Rev Med. 2009;60:207-19. doi: 10.1146/annurev.med.60.041807.132435.
8
Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells.Akt/PKB的过表达调节癌细胞中的N-肉豆蔻酰转移酶活性。
J Pathol. 2009 Jul;218(3):391-8. doi: 10.1002/path.2550.
9
Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.三(二亚苄基丙酮)二钯,一种N-肉豆蔻酰转移酶-1抑制剂,在体外和体内均对黑色素瘤生长有效。
Clin Cancer Res. 2008 Sep 15;14(18):5743-8. doi: 10.1158/1078-0432.CCR-08-0405.
10
A quantitative atlas of mitotic phosphorylation.有丝分裂磷酸化定量图谱。
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31.

NMT1 (N-myristoyltransferase 1).

作者信息

Selvakumar Ponniah, Kumar Sujeet, Dimmock Jonathan R, Sharma Rajendra K

机构信息

Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N OW8, Canada (PS, SK, RKS); Cancer Research Unit, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, SK S7N 4H4, Canada (PS, SK, RKS); Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada (JRD).

出版信息

Atlas Genet Cytogenet Oncol Haematol. 2011 Jan 7;15(7):570-575. doi: 10.4267/2042/45997.

DOI:10.4267/2042/45997
PMID:22977462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3439497/
Abstract
摘要