Yur'eva E A, Sukhorukov V S, Murashov A N, Pimenov M S, Ilyushina I A, Dreval A A
Moscow Research Institute of Pediatrics and Pediatric Surgery, Moscow, Russia.
Bull Exp Biol Med. 2012 Aug;153(4):459-62. doi: 10.1007/s10517-012-1740-6.
Atherosclerotic plaque formation and vascular calcinosis were modeled in a subchronic experiment. Reduced HDL and elevated LDL concentrations, increased atherogenic index and albumin toxicity index, and high blood levels of triglycerides and uric acid were early markers of pathology. Xydiphone in combination with vitamin D effectively reduced these changes and the degree of vascular calcinosis.
在一项亚慢性实验中模拟了动脉粥样硬化斑块形成和血管钙化。高密度脂蛋白降低、低密度脂蛋白浓度升高、致动脉粥样硬化指数和白蛋白毒性指数增加，以及血液中甘油三酯和尿酸水平升高是病理早期标志物。西地芬与维生素D联合使用可有效减轻这些变化以及血管钙化程度。
