四肽H-Ala-Glu-Asp-Arg-OH刺激细胞骨架蛋白和核基质蛋白的表达。
Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins.
作者信息
Khavinson V Kh, Lin'kova N S, Polyakova V O, Kvetnoy I M, Benberin V V, D'yakonov M M, Titkov Yu S
机构信息
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
出版信息
Bull Exp Biol Med. 2012 Aug;153(4):559-62. doi: 10.1007/s10517-012-1766-9.
Tetrapeptide H-Ala-Glu-Asp-Arg-OH enhances the expression of cytoskeletal (actin, tubulin, vimentin) and nuclear matrix proteins (lamin A, lamin C) in cultured mouse embryonic fibroblasts by 2-5 and 2-3 times, respectively. Thus, the previously reported cardioprotective activity of this tetrapeptide is determined by its capacity to activate synthesis of cytoskeletal and nuclear matrix proteins, which stimulates cell proliferation and reduces apoptosis.
四肽H-Ala-Glu-Asp-Arg-OH可分别使培养的小鼠胚胎成纤维细胞中的细胞骨架蛋白（肌动蛋白、微管蛋白、波形蛋白）和核基质蛋白（核纤层蛋白A、核纤层蛋白C）的表达提高2至5倍和2至3倍。因此，此前报道的该四肽的心脏保护活性取决于其激活细胞骨架蛋白和核基质蛋白合成的能力，这种能力可刺激细胞增殖并减少细胞凋亡。
Zotero 插件